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234 Cardio Diabetes Medicine 2017

Remnant Lipo Proteins –

Residual Vascular Risk

Dr. R. Sarvanan, MD.,
Chairman, R.R.Hospital ,Thoothukudi

ABSTRACT:
This article focusses on the Remnant Lipoproteins
levels and the Residual vascular risks associated. In-
vitro animal studies and various observational studies
clearly show increased levels of Remnant Cholesterol
causes atherosclerosis in the same way as increased
LDL cholesterol. They also show that elevated LDL-C
are associated with atherosclerotic vascular events
but increased levels of RLP s is also correlated with
low grade inflammation. They are measured in the
nonfasting state as Total Cholesterol minus LDL-C
minus HDL-C.Even an increment of 39 mg/dl is asso-
ciated with 2.8 fold increase in incidence of vascular
events.
Randomised trials using fibrates for elevated tri-
glyceride levels slow benefits. However large ran-
domised trials with primary target of lo wering RLP s C-CHOLESTEROL
are still missing even T-TRIGLYCERIDES
though so many new Therapeutic perspectives are Lipoproteins transport water insoluble Triglycerides
in the pipeline and cholesterol between tissues and organs in the
body. They consist of a core of Hydrophobic choles-
Definition and Introduction terol esters and triglycerides surrounded by Hydro-
Despite the success of statins in reducing athero- philic monolayer of Phospholipids, free cholesterol
sclerotic cardiovascular disease (ASCVD) there re- and apolipoproteins .
mains a large residual risk for recurrent events even The different classes are Chylomicrons, Chylomicron
in statin treated patients. Although residual risk may Remnants Very Low Density Lipoproteins(VLDL) In-
be attributable to many factors like Diabetes,Obesi- termediate Density lipoproteins (IDL) LDL, Lipopro-
ty,Alcoholism there is considerable interest in Lipo- tein (a) and High Density Lipoprotein (HDL).
protein related residual risk beyond LDL-C Reduction.
Triglycerides (TGL), a surrogate marker of TG-rich
remnant Lipoprotein have been a particular source
of interest because of consistent association with
ASCVD and the increase in TG levels in relation to
the Obesity Epidemic.

GCDC 2017