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              intervening MI.  The  guidelines  urge  restraint  in the   computed  tomography. Circulation.  2003 Jun 17;107(23):2900-7.  Epub
              use of routine testing in the follow-up of patients with   2003 May 27.
              SIHD if they have not had a change in clinical status .  8.  Kevin C  Allman, Leslee  J Shaw, Rory Hachamovitch, James E Udelson.
                                                                   Myocardial viability  testing  and  impact of revascularization  on prognosis
              Summary                                              in  patients  with  coronary  artery  disease  and left  ventricular  dysfunction:
                                                                   a meta-analysis. J Am Coll Cardiol. 2002;39(7):1151-1158.
                     The decision for revascularization should fo-
              cus on improvement of survival in patients with SIHD   9.  Pim AL. Tonino, Bernard De Bruyne, Nico H.J. Pijls, Uwe Siebert, Fumiaki
                                                                   Ikeno, Marcel  van `t Veer, et al. Fractional Flow Reserve  versus  Angi-
              and high clinical risk  for  mortality  with GDMT and   ography for  Guiding Percutaneous  Coronary Intervention.  N Engl J Med
              in those who have inadequate control of symptoms     2009; 360:213-224
              and quality of life despite GDMT. Recommendations   10. Nico HJ Pijls, Pepijn van Schaardenburgh, Ganesh Manoharan, Eric Boers-
              include  CABG for patients with  significant  left main   ma, Jan-Willem  Bech, Marcel  van’t Veer, et al. Percutaneous  Coronary
              CAD, triple-vessel CAD, or proximal left anterior de-  Intervention  of  Functionally  Nonsignificant  Stenosis  5-Year  Follow-Up  of
              scending (LAD) disease  plus  one other major  cor-  the DEFER Study. J Am Coll Cardiol. 2007;49(21):2105-21
              onary  artery.  CABG  is  reasonable  for  patients with
              double-vessel CAD who have evidence of severe or
              extensive myocardial ischemia or mild to moderate
              LV  systolic  dysfunction  with viable  myocardium  in
              the region of intended revascularization.  CABG is
              given  preference  over  PCI in patients with complex
              three-vessel  disease  and those with  diabetes melli-
              tus. It is discouraged to use PCI or CABG for single- or
              double-vessel  CAD without  significant involvement
              of  the proximal LAD  artery in  the absence of  unac-
              ceptable angina after an adequate trial of GDMT, par-
              ticularly if noninvasive testing data indicate that they
              have  only a small area of viable myocardium  or  do
              not have extensive ischemia or reduced LV ejection
              fraction.
              References:
              1.  Marzilli  M, Merz CN, Boden WE,  et al: Obstructive  coronary athero-
                sclerosis  and  ischemic  heart  disease:  An  elusive  link!  J  Am  Coll  Cardiol
                60:951, 2012.
              2.  Pepine CJ,  Douglas PS: Rethinking stable ischemic heart disease: Is this
                the beginning of a new era? J Am Coll Cardiol 60:957, 2012.
              3.  Patrick W. Serruys, Marie-Claude Morice, A. Pieter Kappetein, Antonio
                Colombo, David R. Holmes, Michael J. Mack, et al. Percutaneous Coronary
                Intervention  versus  Coronary-Artery Bypass  Grafting for Severe  Coronary
                Artery Disease. N Engl J Med 2009; 360:961-972
              4.  Davies RF, Goldberg AD, Forman S, Pepine CJ, Knatterud GL, Geller N et
                al. Asymptomatic Cardiac Ischemia Pilot (ACIP) study two-year follow-up:
                outcomes of patients randomized to initial strategies of medical therapy
                versus revascularization. Circulation. 1997 Apr 15;95(8):2037-43.
              5.  Erne P, Schoenenberger AW, Burckhardt D, Zuber M, Kiowski W, Buser PT
                et al. Effects of percutaneous coronary interventions in silent ischemia af-
                ter myocardial infarction: the SWISSI II randomized controlled trial. JAMA.
                2007 May 9;297(18):1985-91.
              6.  Madsen JK, Grande P, Saunamäki K, Thayssen P, Kassis E, Eriksen U, et
                al. Danish  multicenter  randomized study  of invasive  versus  conservative
                treatment in patients with inducible ischemia after thrombolysis in acute
                myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarc-
                tion. Circulation. 1997 Aug 5;96(3):748-55.
              7.  Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Berman DS. Compar-
                ison  of  the  short-term  survival  benefit  associated  with  revascularization
                compared with medical therapy in patients with no prior coronary artery
                disease  undergoing  stress  myocardial perfusion  single  photon  emission


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