Page 24 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

C. Transcription and translation
Genomic DNA Nucleus Cytoplasm
Nuclear pore
RNA polymerase
Transcription
factors and
signal
RNA
a 5’ 2 Translation in ribosomes
Transcription Primary
RNA mRNA
Ribosome
subunits 3’
b end
Splicing
Stop
tRNA The Cell II
mRNA amino
c acids
mRNA export
d Plate 1.5
mRNA Growing
Ribosomes breakdown Ribosome peptide chain
tRNA amino acids
1 Cytosolic Finished
protein Start peptide chain
e tRNA 5’ end
Translation amino acids
Ribosomes Membrane-bound
and export proteins
Control (cf. Plate F.)
D. Transcription and splicing E. Protein coding in DNA and RNA
Coding for amino acid no. ... 3’ 5’
1–15 16–44 45–67 DNA T A A A A T G C T C T C
Genomic
DNA Codogen
Transcription Transcription and Splicing
Export from nucleus
5’
Primary end Exon Intron 3’
end
RNA
(hnRNA) 5’ 3’
mRNA A U U U U A C G A G A G
Codon
Anti-
3’-poly-A tail Reading direction codon
C U C
5’ A A A A A
cap tRNA Glu C Ribosome
5’ C
Splicing Introns Protein A
NH 2 Ile Leu Arg Glu
A
mRNA A A A A 11
11
1 15 44 67 Growth of peptide chain
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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