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28   Chapter 2.  Pain

                 an unpleasant sensory and emotional experience associated with
             actual or potential tissue damage, or described in terms of such
             damage.
                Pain is usually transitory, lasting only until the noxious
           stimulus is removed or the underlying damage or pathology
           has healed- this is acute pain. For example, acute pain may be
           exacerbated during regular treatment due to the need for
           manipulation; wound cleansing, dressing removal and re-
           application, debridement (White   2008  Upton  2011a ,  b ).
                                            ;
              However, some painful conditions may persist for years.
           This is chronic pain, as opposed to acute pain that may be
           experienced for a relatively brief period (e.g. during dressing
           change). The definition of chronic pain is rather arbitrary,
           however. The most commonly used definition being pain of
           greater than 3 or 6 months since the onset of pain (Turk and
           Okifuji   2002 ) though others have suggested a 12 month mark
           (Spanswick and Main   2000 ). Others apply  acute  to pain that
           lasts less than 30 days,  chronic  to pain of more than 6 months
           duration, and  subacute  to pain that lasts from 1 to 6 months
           (Thienhaus and Cole   2002 ). Alternatively, a compromise defi-
           nition is that chronic pain is “pain that extends beyond the
           expected period of healing” (Turk and Okifuji   2002 ) and one
           that will be adopted here. Chronic pain may be an important
           component of care for patients with wounds given the poten-
           tial chronicity of their wound and the regular requirement for
           dressing change.
              In addition to the distinction between acute and chronic
           pain, there are many forms of pain, which may be useful to
           distinguish here. Hence, nociceptive pain is pain that happens
           because of tissue damage or inflammation and is caused by
           stimulation of peripheral nerve fibres that respond only to
           stimuli approaching or exceeding harmful intensity:
               Pain that arises from actual or threatened damage to non-neural
             tissue and is due to the activation of nociceptors (ISAP   2012 )

                Nociceptors are the nerves which sense and respond to
           parts of the body, which suffer from damage. They signal  tissue
           irritation, impending injury, or actual injury. When  activated,
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