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PREFACE










            This is the seventh edition of Hematology: Basic Principles and Practice.   Hematopathology at the University of Utah School of Medicine. He
            This textbook has, over the last 30 years, become a staple for many   has helped to improve the quality of the photomicrographs that play
            students  of  hematology.  It  is  our  intent  that  this  seventh  edition   a prominent role in many of our chapters. Additionally, Dr. Salama
            continue to fill this role. The goal of this venture has always been,   has developed a virtual microscopy system that will allow the readers
            and continues to be, the creation of a volume of information that   to  better  examine  relevant  histopathology  of  a  number  of  blood
            summarizes the overall body of knowledge known as hematology. In   disorders. We believe this system will be useful to our readership in
            this time of online publishing and rapid publication, as well as the   order  to  better  appreciate  the  critical  aspects  of  hemato-pathology
            availability of numerous search engines that provide algorithms to   needed to practice modern hematology. Dr. Syed Abutalib has also
            assist with patient care, the value of Hematology: Basic Principles and   joined our group and will serve as the editor responsible for monthly
            Practice to our readership is even greater than in the past. Currently,   updates. Dr. Abutalib is a hematologist and medical oncologist at the
            there is a trend to use content-lite vehicles that provide condensed   Midwestern  Regional  Medical  Center  in  Zion,  Illinois.  Syed  is  in
            forms of information to the hematology community. From our per-  clinical practice and a full-time clinician. He has an intense interest
            spective, this bullet point–directed strategy of education dealing with   and extensive track record in medical education. Our editorial team
            complex  science  and  medicine  represents  a  serious  misstep  that   felt that a full-time practitioner would be best suited to determine
            ultimately diminishes the hematology community’s opportunity to   which updates would be of greatest importance to our readership.
            achieve excellence in research and patient care. This edition provides   Several updates will be provided monthly to the readership, and these
            a compilation of chapters that summarizes an in depth analysis of   will be vetted by the other editors working with Dr. Abutalib. These
            hematology. These chapters have been created by luminaries in their   efforts will provide a path by which we can continue to expand and
            respective fields and have been critically evaluated by the editorial   improve  the  content  provided  within  the  text  after  the  time  of
            team. We all understand that the medical literature changes by the   publication. With this mechanism in place we have become a book
            hour, but practice-changing advances are relatively few. These chap-  that can change and evolve over time. Please utilize these updates to
            ters provide a solid foundation with which the readership can assess   better evaluate the the massive wave of new information that we all
            the  significance  of  the  most  recent  advances  in  hematology.  From   encounter.
            these carefully crafted and edited chapters the readership can rapidly   After the completion of this seventh edition we still feel this book
            gain access to a comprehensive body of knowledge that will serve as   is a work in progress. We are still seeking and considering the best
            a  platform  to  better  appreciate  the  rapidly  evolving  literature  in   ways to provide timely information to our readership, and we remain
            hematology  science  and  practice.  Cryptic  summaries  of  complex   humbled by the complexity of this task in this age of rapid com-
            issues that underlie hematology cannot be critically evaluated with a   munication. We will continue to modify this book and have enjoyed
            series of bullet points. Medicine and science are more nuanced and   the challenges we have encountered in its preparation. Over the years,
            require a commitment by the target audience to appreciate where a   we have added additional members to our editorial team to create a
            particular field is and where it is going. Of course, the use of this   book that we can be proud of and that we have certainty will be of
            textbook  requires  an  initial  time  commitment  on  the  part  of  the   use to our readership. We hope that this seventh edition meets our
            reader that ultimately will lead to significant rewards. In the long run   joint expectations and the growing needs of our readership.
            the examination of these chapters is an investment in your intellectual
            development and educational pursuits. To some, this approach might                      Ronald Hoffman, MD
            be considered “old school,” but we believe it really shows prudence                   Edward J. Benz, Jr., MD
            and respect for this incredibly challenging field. It makes hematology                Leslie E. Silberstein, MD
            challenging  and  exciting  again.  The  editorial  team  for  the  sixth                Helen E. Heslop, MD
            edition  has  remained  intact  and  includes  Drs.  Ronald  Hoffman,                     Jeffrey I. Weitz, MD
            Edward  Benz,  Leslie  Silberstein,  Helen  Heslop,  Jeffrey Weitz,  and                   John Anastasi, MD
            John Anastasi. For this seventh edition, Dr. Mohammed Salama has                    Mohammed E. Salama, MD
            joined our team. Dr. Salama is Professor of Pathology and Chief of                        Syed Abutalib, MD
























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