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To the numerous authors who have toiled to create the chapters that constitute this book. Their energy and
perseverance are emblematic of their continued commitment to the value of scholarship and education
in medicine. The work of each of these authors enhances our knowledge of hematology, which ultimately
leads to improved care for patients with blood disorders. To my wife, Nan, and my children, Michael, Judith,
Daniel, and Margot, who continue to support my efforts and help me maintain a firm footing in life. To
President Barack Obama who has created a country in which I am happy to live and who will always be my
role model. To the members of my laboratory and clinical trials groups who make it a pleasure to come to
work each day. This edition would not have happened without the continued support of the staff at Elsevier,
especially Lucia Gunzel, who has made each edition significantly better and who provides the good cheer
that allows us to complete this book. I would also like to acknowledge my colleagues at the Icahn School of
Medicine at Mount Sinai School who continue to value the contribution that this book represents. Last, but
not least, our loyal readers, who have made this book a success for more than 25 years and continue to
value and use it in a manner that enhances their professional pursuits.
Ronald Hoffman, MD
To my wife, Peggy, for your support, inspiration, and partnership; to our children, Tim, Jenny, Julie, and
Rob, for your understanding; to our grandchildren for delighting us during this phase of our lives; to my
mentors, Art Parde, Arthur Nienhuis, Bernie Forget, and David Nathan, for your support and guidance; to
Addy Donnelly and Amy Thorp, for your incredible skill, patience, and good humor throughout this project;
and to the many patients and volunteers whose willingness to participate in clinical research made much of
the knowledge conveyed by this book possible.
Edward J. Benz, Jr., MD
To my friends and family for their love and support; to my mentors, Eugene M. Berkman and Robert
S. Schwartz, who have provided me with invaluable guidance; to my colleagues at the University of
Pennsylvania and Harvard, who have helped me develop academic transfusion medicine programs; and to
the trainees who make this endeavor enjoyable and worthwhile.
Leslie E. Silberstein, MD
To my family, friends, and all of my present and former colleagues and trainees for their support and
encouragement; to all my mentors in hematology who have provided guidance, in particular, Michael Beard
and Malcolm Brenner.
Helen E. Heslop, MD
To my wife, Julia, for her love and unwavering support: I would be lost without her; to my children, Daniel
and Kyle, for their understanding and encouragement; to Gwen, for extending our family; to my colleagues
for providing me with an environment for learning and growth; and to my trainees, for making this all
worthwhile.
Jeffrey I. Weitz, MD
To my respected clinical colleagues with appreciation for trusting me with the diagnostic material from their
patients; to my esteemed teachers, Jim Vardiman, Diana Variakojis, and from long ago, C. Robert Valeri,
for your many lessons focused on things at both ends of the microscope; and to my awesome trainees; it
is always a great pleasure to watch you grow to appreciate the serious, yet amazing, nature of our work.
John Anastasi, MD
I wish to express my appreciation to my family. I am grateful for the support, love, and inspiration from
Nahla, Youssef, and Farah.
Mohamed E. Salama, MD

