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CONTENTS
Contributors ............................................... ix 16. Cell-Cycle Regulation and Hematologic Disorders ......... 213
Preface ................................................... xxi Yun Dai, Prithviraj Bose, and Steven Grant
17. Signal Transduction Pathways........................... 247
PART I Kenneth Kaushansky
Clinical Evaluation of the Patient 18. Hematopoietic Stem Cells, Progenitors, and Cytokines ..... 257
1. Initial Approach to the Patient: History and Physical Kenneth Kaushansky
Examination............................................ 3 19. The Inflammatory Response ............................ 279
Jeffrey S. Warren and Peter A. Ward
Marshall A. Lichtman and Linda J. Burns 20. Innate Immunity ...................................... 293
2. Examination of Blood Cells.............................. 11 Bruce Beutler
Daniel H. Ryan 21. Dendritic Cells and Adaptive Immunity .................. 307
3. Examination of The Marrow ............................. 27 Madhav Dhodapkar, Crystal L. Mackall, and Ralph M. Steinman
Daniel H. Ryan
4. Consultative Hematology................................ 41 PART V
Rondeep S. Brar and Stanley L. Schrier
Therapeutic Principles
PART II 22. Pharmacology and Toxicity of Antineoplastic Drugs ....... 315
The Organization of the Lymphohematopoietic Tissues Benjamin Izar, Dustin Dzube, James M. Cleary, Constantine
S. Mitsiades, Paul G. Richardson, Jeffrey A. Barnes, and
5. Structure of the Marrow and the Hematopoietic Bruce A. Chabner
Microenvironment ..................................... 53 23. Hematopoietic Cell Transplantation ..................... 353
Utpal P. Davé and Mark J. Koury Andrew R. Rezvani, Robert Lowsky, and Robert S. Negrin
6. The Organization and Structure of Lymphoid Tissues ....... 85 24. Treatment of Infections in The Immunocompromised
Aharon G. Freud and Michael A. Caligiuri Host................................................. 383
Lisa Beutler and Jennifer Babik
PART III 25. Antithrombotic Therapy ............................... 393
Epochal Hematology Gregory C. Connolly and Charles W. Francis
7. Hematology of the Fetus and Newborn.................... 99 26. Immune Cell Therapy.................................. 409
James Palis and George B. Segel Carolina Berger and Stanley R. Riddell
8. Hematology during Pregnancy .......................... 119 27. Vaccine Therapy ...................................... 421
Martha P. Mims Katayoun Rezvani and Jeffrey J. Molldrem
9. Hematology in Older Persons ........................... 129 28. Therapeutic Apheresis: Indications, Efficacy, and
William B. Ershler, Andrew S. Artz, and Bindu Kanapuru Complications ........................................ 427
Robert Weinstein
29. Gene Therapy for Hematologic Diseases.................. 437
PART IV Hua Fung and Stanton Gerson
Molecular and Cellular Hematology 30. Regenerative Medicine: Multipotential Cell Therapy for
10. Genetic Principles and Molecular Biology ................ 145 Tissue Repair ......................................... 447
Lynn B. Jorde Jakub Tolar, Mark J Osborn, Randy Daughters, Anannya Banga, and
11. Genomics ............................................ 155 John Wagner
Lukas D. Wartman and Elaine R. Mardis
12. Epigenetics ........................................... 165 PART VI
Bradley R. Cairns The Erythrocyte
13. Cytogenetics and Genetic Abnormalities ................. 173 31. Structure and Composition of the Erythrocyte ............ 461
Lucy A. Godley, Madina Sukhanova, Gordana Raca, and Narla Mohandas
Michelle M. Le Beau 32. Erythropoiesis ........................................ 479
14. Metabolism of Hematologic Neoplastic Cells.............. 191 Josef T. Prchal and Perumal Thiagarajan
Zandra E. Walton, Annie L. Hsieh, and Chi V. Dang
15. Apoptosis Mechanisms: Relevance to the Hematopoietic 33. Erythrocyte Turnover.................................. 495
System............................................... 203 Perumal Thiagarajan and Josef Prchal
John C. Reed 34. Clinical Manifestations and Classification of Erythrocyte
Disorders ............................................ 503
Josef T. Prchal
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