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Preface to the first edition                 vii


           bonemarrow transplantation. Also included is a series of chapters   In summary, we have intended to provide the reader with a
           on pharmaceutical agents currently available to clinical immunolo-  comprehensive and authoritative treatise on the broad subject
           gists, both as anti-allergic and anti-inflammatory drugs, as well as   of clinical immunology, with particular emphasis on the diagnosis
           newer agents with greater specificity for T cell-mediated immune   and treatment of immunological diseases. It is anticipated that
           responses. The section concludes with a series of chapters that   the book will be used most frequently by the physician specialist
           address established and potential applications of therapeutic   practicing clinical immunology, both in his or her role as a
           agents and approaches that are largely based on the new techniques   primary physician and as a subsequent consultant. It is hoped,
           of molecular medicine. In addition to pharmaceutical agents the   however, that the book will also be of considerable utility to the
           section deals in detail with such subjects as apheresis, cytokines,   non-immunologist. Many of the diseases discussed authoritatively
           monoclonal antibodies and immunotoxins, gene therapy and   in the book are diseases commonly encountered by the generalist
           new experimental approaches to the treatment of autoimmunity.   physician. Indeed, as noted, because clinical immunology involves
           The book concludes with a section devoted to approaches and   diseases of virtually all organ systems, competence in the diagnosis
           specific techniques involved in the diagnosis of immunologic   and  management  of  immunological  diseases  is  important  to
           diseases. Use of the diagnostic laboratory in evaluation of complex   virtually all clinicians. The editors would be particularly pleased
           problems of immunopathogenesis has been a hallmark of the   to see the book among the references readily available to the
           clinical immunologist since inception of the discipline and   practicing internist, pediatrician and family physician.
           many clinical immunologists serve as directors of diagnostic
           immunology laboratories. Critical assessment of the utilization of                           Robert R. Rich
           techniques ranging from lymphocyte cloning to flow cytomeric                             Thomas A. Fleisher
           phenotyping to molecular diagnostics are certain to continue as                        Benjamin D. Schwartz
           an important function of the clinical immunologist, particularly                          William T. Shearer
           in his or her role as expert consultant.                                                    Warren Strober
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