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Principles of Hemostasis and
Principles of Blood Collection and

27 Trombosis: Blood Coagulation Factors

CHAPTER Processing

and Natural Coagulant Systems

KEY TERMS

activated clotting tim e brinolysis procoagulant
activated partial throm boplastin tim e brin split products protein C

antithrom bin nal com m on pathway protein S
cell-based coagulation international norm alized ratio (INR) prothrom bin group

cellular proteases intrinsic pathway prothrom bin tim e (PT)
coagulation inhibitor kinin system serum

com plem ent system lysosom es throm bom odulin
contact group mixing study tissue factor

D-dim er natural anticoagulant system s warfarin
extrinsic pathway new oral anticoagulants zym ogen

factor V (Leiden) plasm inogen
brinogen group plasm inogen activators

LEARNING OUTCOMES

Blood coagulation factors Normal protective mechanisms against

■ Explain the procedure for naming the coagulation factors. thrombosis

■ List the principal coagulation factors. ■ Explain the effect of normal blood ow and the removal of sub-

■ Name the three groupings of coagulation factors and describe their stances from the circulation on protecting the body from thrombosis.

similarities. ■ Describe the activities of antithrombin as a normal body defense

■ Describe the individual functional characteristics of each of the mechanism.

coagulation factors. ■ Name the two heparin-dependent thrombin inhibitors and describe

■ Name the four basic phases of blood coagulation. their role as part of the natural anticoagulant system.

■ Describe the sequence of events in the extrinsic pathway. ■ Describe the functions of protein C and protein S.

■ Describe the sequence of events in the intrinsic pathway. ■ Explain the activities of the cellular proteases and the role of speci c

■ Describe the sequence of events in the common coagulation body cells in the production of coagulation factors and cofactors.

pathway. ■ Name and describe the assay techniques that can be used for the

Compare clot-based coagulation and cell-based coagulation detection of brin split products.

processes.

■ Describe the importance of vitamin K in hemostasis.

■ De ne the term brinolysis, and describe the major components of

brinolytic system and why brinolysis is necessary NOTE:

■ Name and explain the principles of the basic and global ■ indicates MLT and MLS core content

laboratory tests that are used in assessing blood coagulation indicates MLT (optional) and MLS advanced content

factors.

BLOOD COAGULA ION FAC ORS the or ation o a c ot (thro bus) usua y occurs as art o

the nor a rocess o he ostasis. T e so ub e b oo coagu-

B ee ing ro s a b oo vesse s ay be sto e by ation actors are critica co onents in the or ation o a

vasoconstriction an the or ation o a ate et ug, but thro bus.

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