Page 105 - Clinical Hematology Atlas

CHAPTER 9 LYMPHOCYTE MATURATION 89

LYMPHOCYTE

Nucleus Cytoplasm
B
FIGURE 9–6B Schematic of
A lymphocyte. C
FIGURE 9–6A Small lymphocyte. FIGURE 9–6C Large lymphocyte.
Note irregular nucleus and more
abundant cytoplasm than small
lymphocyte.

D E
FIGURE 9–6D Large granular lymphocyte. Note FIGURE 9–6E Electron micrograph of lymphocyte
prominent azurophilic granules in cytoplasm. (330,000).

SIZE: 7-18 mm
NUCLEUS: Round to oval; may be slightly indented
Nucleoli: Occasional
Chromatin: Condensed; clumped; blocky, smudged
CYTOPLASM: Scant to moderate; sky blue; vacuoles may be present
Granules: None in small lymphocyte; may be a few azurophilic in larger lymphocytes; if
granules are prominent, the cell is called a large granular lymphocyte.
N/C RATIO: 5:1 to 2:1
Reference Interval (for combined small and large lymphocytes):
Bone Marrow: 5% to 15%
Peripheral Blood: 20% to 40%
Refer to Table 1-1 for more examples.