Page 167 - Clinical Hematology Atlas

CHAPTER 15 ACUTE MYELOID LEUKEMIA 151

MORPHOLOGY
Peripheral Blood: Blasts with some maturation
6 Auer rods (see Figures 15-2, A and B)
Bone Marrow: Blasts, some with large azurophilic granules, perinuclear hof
6 Auer rods
,90% of nonerythroid cells are blasts
$10% neutrophilic component
,20% monocytic component
CYTOCHEMISTRY
Myeloperoxidase: positive (see Figure 15-2, E)
Sudan Black B: positive (see Figure 15-2, F)
GENETICS
Subset with t(8;21) is designated as AML with recurrent genetic abnormalities. In this sub-
set, blasts are large with abundant basophilic cytoplasm, azurophilic granules, and possible
perinuclear hofs.
IMMUNOPHENOTYPE
CD13 , CD33 , CD65 , CD11b , CD151, HLA-DR 6
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