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CHAPTER 4  MEGAKARYOCYTE MATURATION    39

                                            MEGAKARYOCYTE (MK-III)

                                                                                    Platelets
                                                                                       Nucleus

                                                                                          Cytoplasm










                                                           B                            Platelets
                                                           FIGURE 4–6B  Megakaryocyte, MK-III, schematic.



                 A
               FIGURE 4–6A  Megakaryocyte, MK III—bone
               marrow (3500).


               SIZE:  20-90 mm
               NUCLEUS:  2-32 lobes (8 lobes: most common)
               NOTE:  The size of the cell varies according to
                  number of lobes present.
               CYTOPLASM:  Blue to pink; abundant
               Granules:  Reddish blue; few to abundant
               N/C RATIO:  Variable
               REFERENCE INTERVAL:
               Bone Marrow:  5-10 per 103 objective
                  (3100 magnification)
                  1-2 per 503 objective (3500 magnification)
               NOTE:  Megakaryocytes are usually reported as
                  adequate, increased, or decreased and not as a
                  percentage.
               Peripheral Blood:  0%
                                                              C
                                                           FIGURE 4–6C  Electron micrograph of megakaryo-
                                                           cyte (316,500).
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