Page 7 - Drug Discovery and Development: Prospects and Challenges
P. 7

Contents




                 Summary                                                 vii

             Introduction                                                 1
             Natural Medicines According to Islamic and Old Malay
                 Scriptures                                               3
             Progress in Pharmaceutical Development                       5
             Source of Drugs                                              7
             Journey in Research: A Personal Experience                   9
             Isolation and Characterisation Studies                       9
             In Vitro and In Vivo Studies                                13
                 Anti-cancer/Cytotoxicity                                14
                 Anti-hyperglycemic                                      15
                 Anti-obesity                                            19
                 Wound Healing                                           20
             Drug Development Process                                    21
             Importance of Animal Study                                  22
             Drug Formulation                                            23
             The Miracle Plant, Centella asiatica                        27
             Introduction of C. asiatica                                 27
             Wound Healing Process                                       29
             Hydrogel                                                    30
             Development of Pegaga Research: From Laboratory to Serum X   31
                 Hydrogel Formulation using C asiatica                   31
                 Pegaga Extraction                                       32
                 Optimisation of Fractionation                           32
                 HPLC Analysis                                           34
                 Upscale Production of Pegaga Hydrogel                   35
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