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An Open Environment CT-US Fusion
Figure 5. HU accurately predicts the tumor fat content. (a) Fat, as measured from histological slices, decreases with increasing tumor area
(r2 = 0.51, slope = 20.3). (b) Box plot of average CT histograms show the fat shifted HU values in small tumors. (c–e) Average histograms of tumors in
three tumor size groups show the presence of a tail in the range of HU associated with fat. Based on CT images and histology, fat content decreases
with increasing tumor volume.
doi:10.1371/journal.pone.0027372.g005
Figure 6. Combined CT/US characterizes tissue. (a) CT slice of a hindlimb tumor corresponding to the US slice in (b). The segmented CT slice is
shown in (c) and overlaid on the US image in (d). The combined segmented CT/US image identifies fat proximal to and surrounding the tumor during
ultrasonic imaging, with registration accuracy on the order of 1 mm. Nearby bone is obvious in the CT image (c) but not immediately visualized by US
(b).
doi:10.1371/journal.pone.0027372.g006
PLoS ONE | www.plosone.org 6 November 2011 | Volume 6 | Issue 11 | e27372
