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Protein Neighborhoods of the Mucosal Interface

Figure 6. Heatmap view of proteins identified by shotgun proteomics. Horizontal tree indicates 18 independent lavage samples. Vertical
tree indicates the 49 proteins analyzed, and the protein identities are listed on the right. Three of the proteins clusters showed biogeographic
features are bracketed.
doi:10.1371/journal.pone.0026542.g006

several of these proteins for individual analysis with regard to showed a similar pattern of lower expression in the proximal colon
biogeographical expression levels (Fig. 7). First, the immunoglob- compared to the distal colon (Fig. 7a and b). This is consistent with
ulin-related proteins Ig gamma-1 chain C region (IGHG1), Ig the abundance of plasma cells and epithelial specialization for
alpha-2 chain C region (IGHA2), Ig kappa chain V-III region VG immunoglobulin transcytosis at this anatomic location. Second, a
(KV309), and polymeric immunoglobulin receptor (PIGR) all number of members of the elastase subfamily of serine hydrolases

PLoS ONE | www.plosone.org 8 November 2011 | Volume 6 | Issue 11 | e26542