Page 34 - REC :: M.Tech. BioTech Curriculum and Syllabus - R2019

Methods of measuring process variables –Temperature – Flow measurement and control – Pressure
measurement and control – Agitation – shaft power, rate of stirring – Foam sensing and control – Microbial
biomass – Measurement and control of Dissolved oxygen – Inlet and outlet gas analysis – pH measurement and
control.
Total Contact Hours : 45

Course Outcomes:
Select appropriate bioreactor configurations and operation modes based upon the nature of bioproducts and

cell lines and other processcriteria.
 Apply their knowledge of transport phenomena in designingfield.
 Plan a research career or to work in the biotechnology industry with strongfoundation.
 Design bioreactor, scale up and troubleshooting the problems inbioreactors.
Integrate research lab and Industry; identify problems and seek practical solutions for large scale

implementation of Biotechnology with process controlexpertise.

Text Book(s):
Mansi,E.M.T.EL., Bryce,C.F.A., Demain, A.L. andAllman,A.R.,“Fermentation Microbiology and
1
Biotechnology”, Taylor and Francis,2006.
Mann, U., “Principles of Chemical Reactors Analysis & Design: New tools for Industrial Chemical Reactor
2
Operations “, Willey–VCH,2009.

Reference Books(s) / Web links:
Impre, J.F.M.V., Vanrolleghem, P.A. and Iserentant, D.M., “Advanced Instrumentation, Data Interpretation
1
and Control of Biotechnological Processes”, Kluwer Academic Publishers,2010.
nd
2 Shuler, M.L. and Kargi, F., “Bioprocess Engineering: Basic Concepts”, 2 Edition, Prentice Hall, 2001.
Towler, G. and Sinnott, R., “Chemical Engineering Design: Principles, Practice, Economics of Plant and
3
Process Design”, Butterworth – Heinemann ltd., Elsevier,2008.

BY19P25 BIOPROCESS MODELING AND SIMULATION Category L T P C
3 0 0 3

Objectives:
This course aims at imparting knowledge about the different types of bioreactors and its models for non-

ideal behaviour.
 The students will learn about the different software solution strategies for bioprocess models.

UNIT-I CONCEPTS AND PRINCIPLES 9
Introduction to modelling – Systematic approach to model building – Material and energy balance –
Classification of models – General form of dynamic models dimensionless models – General form of linear
systems of equations nonlinear function – Conservation principles thermodynamic principles of process systems
UNIT-II MODELS 9
Structured kinetic models – Compartmental models (two and three) – Product formation Unstructured models
– Genetically structured models–Stochastic model for thermal sterilization of the medium – Modelling for
activated sludge process – Model for anaerobic digestion – Models for lactic fermentation and antibiotic
production

UNIT-III MODELLINGOFBIOREACTORS 9
Modelling of non-ideal behaviour in Bioreactors – Tanks-in-series and Dispersion models – Modelling of PFR
and other first order processes – Analysis of packed bed and membrane bioreactors Recombinant Cell Culture
Processes – Plasmid stability in recombinant Cell Culture limits toover-expression