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Cardio Diabetes Medicine 2017                                    531


















































                                  Standard Approaches to Therapy Result in
                                    Prolonged Exposure to Elevated Glucose



                                   10%   Diet/Exercise  Sulfonylurea or    Combination     Insulin
                                                          Metformin        Therapy
                                                        Monotherapy                     9.6%
                               at Last   9%            8.6%            9.0%



                               MeanA1C  Visit  8%

                                    7%
                                                                                                     ADA
                                                                                                    Goal
                                                                                                     <7%
                                    6%
                                  Diagnosis      2     3     4     5     6     7    8     9    10
                                                                  Years

                                              At insulin initiation, the average patient had:
                                              ■  5 years with A1C >8%
                                              ■  10 years with A1C >7%

                                                                          Brown JB, et al. Diabetes Care.
                                                                              2004;27:1535-1540.



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