Page 553 - fbkCardioDiabetes_2017

Cardio Diabetes Medicine 2017 529

Initiation & Intensification of

Insulin Therapy in T2DM

Dr. Palaniappen M.D., FICP.,

Sri Sakthi Vinayakar Multispecialitity Hospital &
Dr. V.Palaniyappen’s Diabetes Specialities Centre Guziliamparai-624703. Dindigul (DT)

UKPDS: FIRST 5 YRS INTENSIVE GLYCEMIC CONTROL reduces Micro & Macro vascular Complications in
Future– Metabolic Memory & Legacy Effect

UKPDS: FIRST 5 YRS INTENSIVE GLYCEMIC CONTROL reduces Micro &
Macro vascular Complications in Future–
Metabolic Memory & Legacy Effect

9
Conventional

Median HbA 1C (%) 8 7 Intensive –10 12% P = 0.44
0
6%

6.2% = upper limit of normal range Relative risk reduction (%) P = 0.029 16%
6 –20 P = 0.052
0 25%
0 5 10 15
UKPDS randomized years –30 P = 0.0099

Reproduced from UKPDS Study Group. Lancet 1998; 352:837–853.

Cardio Diabetes Medicine