Page 268 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Lipoproteins
Triacylglycerols Chylomicrons VLDL LDL HDL
0.08
Cholesterol
esters 0.86 g/g 0.12
0.07 0.22 0.30
Cholesterol 0.55 0.42
0.18 0.47
Phospholipids 0.22
0.03 0.04
Proteins 0.02 0.08 0.06 0.15
0.02 0.07 0.04
Diameter 80–500nm ca. 50nm ca. 20nm ca. 10nm
Apolipoproteins AI, B 48 , CII+III, E B 100 , CII+III, E B 100 , CIII, E AI,III+IV, CIII, D Lipid Distribution and Storage I
B. Sources and fate of cholesterol
Synthesis

Hepatocytes Endocytosis
HDL Lysosomal
receptor lipases
LDL LDL Cholesterin
LDL Plate 10.15
Extra- Receptor
LDL HDL hepatic cells
receptor CHO-
esters
LCAT (Store) ACAT Membranes,
Liver contact HDL steroid synthesis

Synthesis
Liver
IDL ca. 0.5g/day
Cholesterol Bile salts
Chylom.
residue
Gut
CHO-esters Diet:
ca. 0.5g/day
Cholesterol Enterohepatic circulation: ca. 24g/day
LPL CHO-esters
Bile
LPL
Unspecific
carboxyl
Mucosa esterase
VLDL Cell
replacement
ca. 1g/day ACAT
Chylo-
microns Portal venous blood
Intestinal Stools:
Blood lymph Synthesis ca. 0.5g/day each 255

Despopoulos, Color Atlas of Physiology © 2003 Thieme
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