Page 264 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Conjugation and secretion of bilirubin in the liver
cMOAT
Albumin
Bilirubin Glucuronyl- Bilirubin-
digluc-
Bilirubin transferase uronide
ATP
UDP-
glucuronic Biliary
acid canaliculi
UTP
Albumin UDP Excretory Liver Function—Bilirubin
Glucose
Blood Hepatocyte
B. Bilirubin metabolism and excretion

Bilirubin
Blood
Hb 230
6.5 mg/day
g/day Plate 10.13
Macro-
phages
Conjugation
(glucuronyltransferase)
Other
sources Bile 15%
Liver enterohepatic
Bilirubin circulation
diglucuronide

Large intestine
Bilirubin Urobilinogen
Greater
circulation
Sterco-
bilinogen
Small intestine

Stercobilin
Urobilin
Kidney
= Anaerobic
bacteria
= O 2
1%
in urine 85% 251
(urobilin, etc.) in feces
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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