Page 300 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Thyroid hormones (overview)
SIH TRH
Thyrocytes Thyroxin
HVL T 4 (tetraiodothyronine)
Capillaries 5’-Deiodase
TSH
Thyroid gland Colloid Triiodothyronine
T 3
Iodine uptake,
hormone synthesis
and secretion
(See B.) Metabolism, growth, maturation, etc.
B. Hormone synthesis and secretion Thyroid Hormones I
1 Thyroglobulin synthesis
Thyroglobulin vesicle
Amino
acids Carbohydrates
Thyroglobulin
Plate 11.11
Peptides
Exocytosis
Ribosomes
Golgi apparatus
Endoplasmic
Capillary reticulum Thyroid cell (thyrocyte) Colloid
2 Iodine uptake, hormone synthesis and storage
SCN – Thyroid
– peroxidase
CIO 4
–
NO 2
–
I pool T 3 /T 4 synthesis T 4
(see C.) T 3
+
I – Na symport
NIS Na + TSH
TSH T 3 /T 4 storage
(bound to thyroglobulin)
3 Hormone secretion
Primary lysosomes
with proteases TSH
Endocytosis
T 4 Fusion
T 3
I –
Thyroglobulin
cleavage
Deiodase
287
MIT, DIT
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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