Page 332 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Nociception B. Referred pain
Sensitization
via bradykinin,
prostaglandin E 2 , Converging
serotonin neurons
Acute From
noxa skin
Ischemia

Nocisensor From
heart
Desensitization
via opioids, Nociception and Pain
SIH, galanin, etc.

C. Ascending and descending tracts for nociception
1 Ascending nociceptive tracts 2 Descending nociceptive tracts
(mainly inhibitory)
Cortex Plate 12.5
Medial
thalamus
Lateral
thalamus
Hypo- Hypo-
thalamus thalamus

Skin of face (and cornea) Central
gray layer Lateral
Nocisensors reticular
C fiber formation
Aδ fiber
Brain stem
Trigeminal
nerve Nucleus Medial
raphe reticular
magnus formation
Motoaxon
Skin (trunk, limbs) Spinothalamic
tract Segmental
inhibition
Nocisensors (Aβ afferents)

Aδ fiber Spinal cord
C fiber

Sympathetic Motoaxon 319
axon (After R. F. Schmidt)
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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