Page 245 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Fluid Exchange at Capillaries
Arteriole Vein kPa mmHg
Lymph 4.0 ∆P 30
ca. 10% 3.5 ∆π
ca. 90% 25
post- 3.0
pre- capillary
capillary Reabsorption resist- 2.5 20
resist- Filtration ance
ance (100%) 2.0 15
Interstitial space
P eff = (P cap – P int )– σ· R· T· ∆C Prot
Filtration = Reabsorption + Lymphatic drainage = ∆P– ∆π (kPa,mmHg)
B. Edema Formation

Edemas
Circulation Capillaries Kidney Liver

Plate 7.31

Systemic: Systemic: Glomerular Liver damage
heart failure anaphylaxia, damage (e.g. cirrhosis)
etc. sepsis, etc. (nephrotic
Local: Local: syndrome)
venous thrombosis, inflammation etc.
inflammation, etc. Local:
Protein Protein (portal vein)
Histamine etc. loss formation
Congestion
Venous congestion Precapillary vasodilation Plasma proteins

Ascites
P cap σ Prot ∆C Prot
+
Na metabolism
+
Na uptake high, ∆P ∆P
+
Na retention
(e.g. renal failure) ∆π ∆π = σ Prot · R · T · ∆C Prot
Lymphatic
drainage
+
Na balance positive ECV
Edema Compression of
lymphatic vessels
+
Na retention Systemic
Obliteration
(radiotherapy)
Renin-Angiotensin Blood volume Obstruction
Lymph (bilharziasis)
Renal blood flow P int 235

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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