Page 331 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Peripheral Mechanisms of Pain
Injury
Necrosis
Pathogen
Blood clotting Ischemia Non-noxious
stimuli
Inflammation Proteins
Noxious
stimuli
Histamine Bradykinin Serotonin K + H +

Vasodilation, Hyper-
PGE 2 vascular permeability algesia
Leukotrienes Allodynia
Edema formation
Pain
Tissue pressure
Plate 10.12
Sensitization Nociceptors
CGRP, SP Pain
B. Referred Pain C. Pain Relief

Converging Perception
In- neurons Suffering
farction
5
Anesthesia, Thalamus
alcohol

Central
Morphine grey matter
Pain sensation 4
1 Referred pain Raphe
3 nuclei
Electroacupuncture,
transcutaneous Associated
nerve stimulation autonomic
Morphine reaction, motor
Cooling, response
+
Na channel blocker Anterior
column
Contusion 2 Inhibitory
pain tract
4
2
Projected pain 1 6
Cooling, Trans-
PGE synthesis ection
inhibitor
321
3 Phantom pain
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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