Page 335 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
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A.  Diseases of the Retina
                             Retinitis pigmentosa
                               Macular degeneration
                        Retinal detachment
       b                                    3        Electroretinogram
                                               Light
                       Rods       Phagocytosis  b          c
                       Cones
                 Hc               Degeneration of    d
                                  the photorecept.
                   Bp  Occlusion of  cells                             Retina
                 Am    central artery
       a                                                               the
                                            a
                         Cell death                      Retinal
                 G                   2         Occlusion of  detachment
                                               central artery          Diseases of
       1                      Blindness        1 s
        B.  Diabetic Retinopathy
                                               Normal fundus
                  Diabetes mellitus
       Capillary                                                       Plate 10.14
                 Glucose

              Sorbitol  AGE
        Pericyte
                         Thickening of
              Swelling   capillary wall

                    Vessel narrowing
                       Ischemia
                       Vessel proliferation
                       Bleeding
                              Retinopathy (loss of vision)
                                  Photo: Hollwich F. Taschenatlas der Augenheilkunde. 3rd ed. Stuttgart: Thieme; 1987
        C.  Night Blindness and Color Blindness
        Vitamin A deficiency
                             Red blindness Green blindness
                             (protanopia)  (deuteranopia)
         all-trans-vitamin A  15

        11-cis-vitamin A
                  Meta-    10
                  rhodopsin                       Protanopia: no number
         11-cis-retinal   Absolute differential threshold  5
         Rhodopsin                   Norm
          Light perception  0 400  500  600 nm
             Night blindness
                           2 Color blindness                          325
       1 Visual pigment deficiency       3 Test charts  Deuteranopia: no number
       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
       All rights reserved. Usage subject to terms and conditions of license.
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