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CoHoRT DESIGn  n  71



             methodology for example the quality assess-  assignment of subjects to groups. Although
             ment of included studies.                the groups in a cohort design may not be as
                 In  summary,  Cochrane  reviews  pro-  comparable  as  randomly  assigned  groups,   C
             vide consumers with readily accessible evi-  archival records or data on relevant variables
             dence  on  the  effectiveness  of  health  care   can be used to compare cohorts that received
             interventions.                           a treatment with those that did not. Because
                                                      simple  comparisons  between  cohorts  may
                                    Josephine Hegarty  suffer  from  a  number  of  design  problems,
                                        Eileen Savage  such as biased sample selection, intervening
                                                      historical events that may influence the out-
                                                      come  variable,  maturation  of  subjects,  and
                                                      testing  effects,  a  strong  cohort  design  can
                      Cohort design                   account for many of these threats to the inter-
                                                      nal validity of a study.
                                                          There  are  two  major  types  of  cohort
             A cohort design is a time-dimensional design   design: the cohort design with treatment par-
             to examine sequences, patterns of change or   titioning and the institutional cycles design.
             growth,  or  trends  over  time.  A  cohort  is  a   In a cohort design with treatment partition-
             group with common characteristics or expe-  ing, respondents are partitioned by the extent
             riences during a given time period. Cohorts   of treatment (amount or length) received. In
             generally refer to age groups or to groups of   the  institutional  cycles  design,  one  or  more
             respondents who follow each other through   earlier cohorts are compared with the experi-
             formal  institutions  such  as  universities  or   mental cohort on the variable(s) of interest. The
             hospitals  or  informal  institutions  such  as   institutional cycles cohort design is strength-
             a  family.  Populations  also  can  be  classified   ened if a nonequivalent, nontreatment group
             according to other time dimensions, such as   is measured at the same time as the experi-
             time of diagnosis, time since exposure to a   mental group. A well-planned cohort design
             treatment, or time since initiating a behavior.   can control for the effects of age or experience
             A cohort might be graduates of nurse practi-  when these might confound results in a pre-
             tioner programs in the years 1995, 2000, 2005,   test–posttest design or when no pretest mea-
             and  2010  or  siblings  in  blended   families.   sures of experimental subjects are available.
             Cohort  designs  were  originally  used  by   Cohort  designs  might  use  a  combination  of
             epidemiologists  and  demographers  but  are   cross-sectional and longitudinal data.
             increasingly  used  in  studies  conducted  by   The  term  cohort  studies  broadly  refers
             nurses  and  other  researchers  in  the  behav-  to  studies  of  one  or  more  cohort  groups  to
             ioral and health sciences.               examine the temporal sequencing of events
                 In  the  most  restrictive  sense,  a  cohort   over  time.  Cohort  studies  may  eventually
             design refers to a quasi-experimental design   lead to hypotheses about causality between
             in  which  some  cohorts  are  exposed  to  a   variables  and  to  experimental  designs.

             treatment  or  event  and  others  are  not.  The   Most  cohort  designs  are  prospective  (e.g.,
             purpose  of  a  cohort  design  is  to  determine   the nurses’ Health Study, in which 100,000
             whether  two  or  more  groups  differ  on  a   nurses  were  enrolled  in  1976  and  have
             specific  outcome  measure.  Cohort  designs   been  followed  since),  although  some  are
             are useful for drawing causal inferences in   retrospective.
             quasi-experimental  studies  because  cohort   There  are  a  number  of  types  of  cohort
             groups are expected to differ only minimally   studies.  The  panel  design,  in  which  one  or
             on  background  characteristics.  Recall  that   more cohorts are followed over time, is espe-
             a  quasi-experimental  design  lacks  random   cially  useful  for  describing  phenomena.
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