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CoRonARY ARTERY BYPASS GRAFT SURGERY  n  91



             in patient’s depression and/or anxiety posto-  to 100% Caucasian. Most investigators found
             peratively.                              that  anxiety  levels  significantly  decreased
                 The most common predictor of postop-  over time and remained linear. Postoperative   C
             erative  anxiety  was  preoperative  anxiety.   anxiety was directly related to perception of
             The impact of gender and age was equivocal   pain with the strongest relationship on post-
             with some studies identifying age as predic-  operative Day 2. neither gender nor age was
             tive and an equal number finding it not pre-  significantly  associated  with  level  of  pain
             dictive.  one  study  identified  a  relationship   (nelson, Zimmerman, Barnason, nieveen, &
             between  age  and  anxiety  (Krannich  et  al.,   Schmaderer, 1998). In a large study with 1,317
             2007). Although younger patients were more   patients, there was a dose–response relation-
             anxious before surgery and showed a decline   ship between state anxiety and risk of death
             in  symptoms  after  surgery,  anxiety  symp-  or  myocardial  infarction  but  no  association
             toms in older patients showed little change   between  self-reported  anxiety  and  athero-
             (Krannich et al., 2007).                 sclerotic  progression  of  grafts  (Wellenius,
                 As with the findings related to anxiety,   Mukamal,  Kulshreshtha,  Asonganyi,  &
             the  most  frequently  identified  predictor  of   Mittleman, 2008). In one study, patients with
             postoperative  depression  was  preoperative   chronic postoperative pain had significantly
             depression.  In  studies  with  women,  female   higher  levels  of  anxiety  and  depression
             gender was a frequently reported predictor   than  those  without  chronic  pain  (Taillefer
             of postoperative depression, but the impact   et al., 2006). The mechanism by which anx-
             of age was equivocal. A conclusion from the   iety  increases  mortality  and  morbidity  is
             systematic  review  was  that  the  most  com-  not yet understood (Rosenbloom, Wellenius,
             mon predictors of postoperative anxiety and   Mukamal, & Mittleman, 2009).
             depression  were  preoperative  levels.  one   Longitudinal studies evaluating depres-
             consistent  recommendation  was  that  clini-  sion reported prevalence rates ranging from
             cians  needed  to  routinely  assess  patients’   16% to 50% preoperatively and from 17% to
             depression  and  anxiety  before  surgery  to   61% postoperatively. Almost all studies used
             identify those patients at greater risk for post-  self-report questionnaires. Subjects’ (n = 50 to
             operative difficulties. In keeping with these   759) mean ages ranged from 54 to 70 years,
             recommendations,  screening  for  depression   most represented a 3:1 male-to-female ratio,
             in patients with coronary heart disease has   and  ranged  from  82%  to  100%  Caucasian.
             recently been recommended by the American   In  addition  to  preoperative  depression  lev-
             Heart Association (Lichtman et al., 2008). In   els,  investigators  have  identified  predictors
             addition, with more women and older adults   of  postoperative  depression  as  poor  social
             undergoing CABG surgery, the impact of age     support, at least one stressful life event in the
             and gender on postoperative recovery needs   last  year,  low  level  of  education,  and  mod-
             to be further explored.                  erate to severe dyspnea (Pirraglia, Peterson,
                 A number of studies have examined the   Williams-Russo,  Gorkin,  &  Charlson,  1999).
             course and outcomes of anxiety for patients   one study found that 6 weeks after surgery,
             undergoing  CABG  surgery.  Longitudinal   fatigued  older  patients  (>65  years)  had  sig-
             studies  evaluating  anxiety  reported  prev-  nificantly  higher  anxiety  and  depressive
             alence  rates  ranging  from  4%  to  50%     symptoms  with  residual  aspects  of  hav-
             preoperatively  and  from  25%  to  61%  post-  ing higher anxiety (experiencing panic and
             operatively.  Almost  all  studies  used  self-  worry) remaining high at 3 months (Barnason
             report  questionnaires for measuring anxiety.   et al., 2008). Depression has consistently been
             Subjects’ (n = 35 to 1,317) mean ages ranged   associated  with  adverse  cardiac  outcomes
             from 54 to 70 years, most represented a 3:1   after CABG surgery. Investigators have found
             male-to-female  ratio,  and  ranged  from  82%   depressive symptoms, pre- or postoperatively
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