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92  n  CoRonARY ARTERY BYPASS GRAFT SURGERY



           predict postoperative cardiac events (unsta-  were  no  significant  differences  (vaccarino,
           ble  angina,  myocardial  infarction,  repeat   2003).  vaccarino,  Abramson,  veledar,  and
   C       CABG,  or  angioplasty),  and  are  positively   Weintraub (2002) found that women under-
           correlated  with  the  rate  of  readmission  for   going  CABG  surgery  were  older,  less  edu-
           cardiac events (Perski et al., 1998; Saur et al.,   cated, had more severe and unstable angina,
           2001; Scheier et al., 1999). Connerney, Shapiro,   had congestive heart failure, had lower func-
           McLaughlin, Bagiella, and Sloan (2001) deter-  tional status, and had more depressive symp-
           mined  that  patients  meeting  criteria  for   toms in the month before surgery. Younger
           major depressive disorder at discharge were   women  were  at  a  higher  risk  of  in-hospital
           significantly  more  likely  to  experience  a   death than men, a difference decreasing with
           cardiac-related  event.  Furthermore,  depres-  age. In a Canadian study, investigators found
           sion was a predictor independent of classic   that  after  adjusting  for  age  and  comorbid
           cardiovascular  risk  factors.  Both  increased   conditions,  female  gender  was  associated
           preoperative  depression  and  postoperative   with a 10% increase in length of stay, a 97%
           anxiety  were  identified  as  risk  factors  for   increase  in  mortality,  and  a  7%  increase  in
           cardiac-related  hospital  admissions  within   overall cost (Bestawros, Filion, Haider, Pilote,
           6  months  of  surgery  (oxlad,  Stubberfield,   & Eisenberg, 2005). In contrast to the earlier
           Stuklis, Edwards, & Wade, 2006). In addition,   findings, a recent study in Japan found that
           postoperative  depression  was  associated   the clinical outcomes for females after CABG
           with  infections,  impaired  wound  healing,   surgery were comparable with those of males
           poor  emotional  and  physical  recovery,  and   (Fukui & Takanashi, 2010).
           a  higher  risk  of  atherosclerotic  progression   Postoperative  neuropsychological  defi-
           among patients with saphenous vein grafts   cits can be complications of cardiac surgery.
           (Doering,  Moser,  Lemankiewicz,  Luper,  &   A  group  of  investigators  in  China  found
           Khan, 2005; Wellenius et al., 2008).     that  patients  undergoing  surgery  with
              Blumenthal et al. (2003) identified higher   bypass  exhibited  more  neuropsychologi-
           mortality  rates  for  patients  with  moderate   cal deficits and anxiety than those patients
           to severe depression at baseline and mild or   whose surgeries were completed off pump.
           moderate to severe depression that persisted   Investigators  found  that  depression  and
           from baseline to 6 months. In contrast to the   anxiety  were  correlated  with  some  factors
           finding of the earlier studies, a more recent   of cognitive dysfunction (Yin, Luo, Guo, Li,
           study  suggested  that  preoperative  depres-  & Huang, 2007). In contrast to these results,
           sion was not associated with a significantly   Stroobant and vingerhoets (2008) found that
           higher  risk  for  mortality,  but  after  adjust-  off-pump patients showed higher cognitive–
           ment for known mortality risk factors, preop-  affective  depression  scores  than   on-pump
           erative anxiety symptoms were significantly   patients.  on-pump  patients  generally
           associated with increased all-cause mortality   showed  no  depression,  whereas  off-pump
           risk.  Investigators  identified  that  there  was   patients had a mild depression that contin-
           a  trend  toward  significance  of  depressive   ued for 3 to 5 years after surgery. In another
           symptoms and mortality risk, but the signif-  study,  no  differences  were  found  between
           icance may have been attenuated by the use   patients  undergoing  surgery  on  and  off
           of psychotropic medications (Tully, Baker, &   pump.  Although  significant  improvement
           Knight, 2008).                           was identified in state anxiety and depres-
              Several  studies  have  addressed  gender   sive symptoms, the number of patients with
           differences in recovery from CABG surgery.   depressive  symptoms  remained  constant.
           In  some  studies,  women  had  more  symp-  Unlike  other  studies,  patients  in  this  sam-
           toms  and  poorer  functioning  after  CABG   ple reported significant subjective improve-
           than  men,  whereas  in  other  studies,  there   ment in concentration and memory (Sandau,
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