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320  P R I N C I P L E S   A N D   P R A C T I C E   O F   C R I T I C A L   C A R E



            Case study
            Mr  Martin  is  a  59-year-old  patient  admitted  for  elective  aortic,   On the basis of the PaCO 2 the SIMV rate was increased to 13 breaths
            mitral and tricuspid valves surgery. His past history includes rheu-  per minute, which corrected the PaCO 2  and pH. FiO 2  was progres-
            matic heart diseases (severe mitral valve regurgitation, aortic ste-  sively decreased from FiO 2  1.00 to 0.40 over the next hour while
            nosis and aortic regurgitation, and moderate to severe tricuspid   pulse oximetry revealed a SpO 2 greater than 98%.
            valve regurgitation) and gout. He has had those valve problems     Mr Martin was switched to CPAP/PS after 30 minutes of spontane-
            for many years, but recently has developed exertional dyspnoea.   ous ventilation on waking, where he sustained adequate ventila-
            Coronary  angiography  was  normal  but  left  ventriculogram     tion.  He  was  assessed  as  suitable  and  extubated  six  hours  post
            reveals severe left ventricle systolic dysfunction. Preoperative tran-  admission. After extubation supplemental face mask oxygen was
            soesophageal echocardiography report reveals dilated left ventri-  applied at 8 LPM to keep SaO 2  >97% and changed to nasal prong
            cle with severe global systolic dysfunction, dilated right ventricle   oxygen at 3LPM three hour post extubation. Lung recovery pro-
            with  moderately  reduced  systolic  function,  severe  pulmonary   gressed  uneventfully,  aided  by  twice-daily  physiotherapy  and
            hypertension and confirmation of pathology of three valves.
                                                              mobilisation. Oxygen was discontinued on day 3.
            Surgery was reported as uncomplicated. Aortic and mitral valves
            were replaced with new mechanical valves and tricuspid valve was   Cardiovascular
            repaired with an annuloplasty ring. Cardiopulmonary bypass had   Rhythm: Epicardial dual-chamber pacing wires were in place, but
            been used for 180 minutes and aortic cross-clamp time was 149   pacing was provided in the AAI mode (demand atrial pacing) at 80
            minutes. An intra-aortic balloon pump catheter was inserted at the   beats/min, with no evidence of AV block. Pacing continued for 24
            end of the case to assist with post operative left ventricle recovery.   hours before sinus rhythm emerged above 80 beats/min, inhibiting
            An infusion of glyceryl trinitrate (GTN) 20 mcg/min was the only   the pacing. After 48 hours of sinus rhythm, the back-up pacing was
            drug infusion in progress.                        turned off and the pacing wires isolated. These wires were removed
                                                              on day 5 without problems. Initially Mr Martin was normotensive
            On admission to the ICU the patient was intubated and ventilated.   with assistance of IABP (augmented diastolic pressure of 120, sys-
            He had left radial arterial and pulmonary artery catheters (PAC) in   tolic  pressure  of  110,  diastolic  pressure  of  55  and  mean  arterial
            situ. Two mediastinal and a pericardial drain tube had been placed   pressure of 80 mmHg), with a cardiac index of 3.1L/min/m . Filling
                                                                                                       2
            and had drained 140 mL of blood to the time of admission. There   pressures were kept at upper normal range with colloid administra-
            was no air leak. A urinary catheter was also present. Early chest   tion as he was vasodilated, with a SVR of 716 dynes/sec/cm . His
                                                                                                         −5
            X-rays  confirmed  ETT,  PAC,  chest  tube  and  IABP  catheter  place-  core  temperature  on  admission  was  36.3°C,  not  requiring  active
            ment. Lung fields were mildly congested and cardiomegaly was   warming. Chest drainage remained modest, with total blood loss
            present.                                          of  150 mL  in  the  first  hour.  Blood  pressure  and  cardiac  output
            The main dimensions of Mr Martin’s progress, care and manage-  remained within normal limits in first 24 hours. IABP was weaned
            ment follow.                                      (ratio  wean)  on  day  1  post  operative  over  a  period  of  6  hours
                                                              without any compromise, and the IABP catheter was removed 24
            Neurological status                               hours post ICU admission.
            Began to wake at 2 hours postoperatively, and was obeying com-
            mands,  able  to  move  all  limbs  with  equal  strength.  Pupils  were   Fluid balance
            normal size and reactive to light. Pain was managed with regular   Chest drainage for the first 4 hours was 400 mL and total drainage
            intravenous  tramadol,  morphine  (boluses)  and  paracetamol     at 48 hours was 750 mL, at which time drains were removed. Mr
            suppositories in initial phase and continued with IV tramadol for   Martin’s urine output remained within 0.5–1 mL/kg/hr with normal
            48 hours and oral paracetamol for 4 days post operative.  serum  urea  and  creatinine.  Hourly  fluid  assessment  was  main-
            Ventilation                                       tained for the duration of ICU stay and a positive fluid balance was
            Initial parameters: ETT secured at lip level 25 cm, equal air entry   recorded  on  both  days  (1100 mL  and  480 mL  respectively).  Oral
            bilaterally.  SIMV  mode,  tidal  volume  (VT)  720 mL  (80 kg),  rate    fluids  were  commenced  3  hours  post  extubation  and  within  24
            10/min, inspiratory flow 40 L/min, PEEP 5 cmH 2 O, FiO 2  1.00, pres-  hours a light diet was being tolerated according to local practice,
            sure  support  10  cmH 2 O,  producing  acceptable  peak  inspiratory   Mr  Martin  remained  in  the  ICU  until  the  second  postoperative
            pressures of 22–26 cmH 2 O.                       morning  and  was  then  discharged  to  the  step-down  unit  after
                                                              removal of all lines and tubes. Mr Martin was started on warfarin
            Admission ABG (after 20 minutes) revealed the following:  tablets for his mechanical valves on day one post operative and the
            ●  PaO 2  366 mmHg                                dosage  was  titrated  by  the  cardiac  team  according  to  his  INR
            ●  PaCO 2  52 mmHg                                results.  DVT  prophylaxis  (heparin)  and  gastric  ulcer  prophylaxis
            ●  pH 7.34                                        (omeprazole) were continued up to day 7 postoperative when Mr
            ●  HCO 3  25 mmol/L                               Martin  was  discharged  from  hospital  with  cardiac  rehabilitation
                  −
            ●  SaO 2  99.9%.                                  program.
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