Page 639 - Hematology_ Basic Principles and Practice ( PDFDrive )
P. 639
Chapter 39 Megaloblastic Anemias 545.e3
91. Duthie SJ, Hawdon A: DNA instability (strand breakage, uracil mis- 114. Antony AC: Prevalence of cobalamin (vitamin B-12) and folate defi-
incorporation, and defective repair) is increased by folic acid depletion ciency in India–audi alteram partem. Am J Clin Nutr 74:157–159,
in human lymphocytes in vitro. FASEB J 12:1491–1497, 1998. 2001.
92. Barnes DE, Lindahl T: Repair and genetic consequences of endogenous 115. Chitambar CR, Antony AC: Nutritional aspects of hematologic dis-
DNA base damage in mammalian cells. Annu Rev Genet 38:445–476, eases. In Shils ME, Shike M, Ross AC, et al, editors: Modern nutrition
2004. in health and disease, ed 10 (50th Anniversary Edition), Baltimore,
93. Lindahl T: Suppression of spontaneous mutagenesis in human cells by Philadelphia, 2006, Lippicott Williams & Wilkins, pp 1436–1461.
DNA base excision-repair. Mutat Res 462:129–135, 2000. 116. Carmel R: Biomarkers of cobalamin (vitamin B-12) status in the
94. Blount BC, Mack MM, Wehr CM, et al: Folate deficiency causes epidemiologic setting: a critical overview of context, applications, and
uracil misincorporation into human DNA and chromosome breakage: performance characteristics of cobalamin, methylmalonic acid, and
implications for cancer and neuronal damage. Proc Natl Acad Sci USA holotranscobalamin II. Am J Clin Nutr 94:348S–358S, 2011.
94:3290–3295, 1997. 117. Yang DT, Cook RJ: Spurious elevations of vitamin B12 with pernicious
95. Ciappio E, Mason JB: Folate and carcinogenesis: basic mechanisms. In anemia. N Engl J Med 366:1742–1743, 2012.
Bailey LB, editor: Folate in Health and Disease, ed 2, Boca Raton, FL, 118. Carmel R, Agrawal YP: Failures of cobalamin assays in pernicious
2010, CRC Press, pp 235–262. anemia. N Engl J Med 367:385–386, 2012.
96. Ames BN, Wakimoto P: Are vitamin and mineral deficiencies a major 119. Merrigan SD, Yang DT, Straseski JA: Intrinsic factor blocking antibody
cancer risk? Nat Rev Cancer 2:694–704, 2002. interference is not detected in five automated cobalamin immunoassays.
97. Dianov GL, Timchenko TV, Sinitsina OI, et al: Repair of uracil Am J Clin Pathol 141:702–705, 2014.
residues closely spaced on the opposite strands of plasmid DNA 120. Fazili Z, Pfeiffer CM, Zhang M: Comparison of serum folate species
results in double-strand break and deletion formation. Mol Gen Genet analyzed by LC-MS/MS with total folate measured by microbiologic
225:448–452, 1991. assay and Bio-Rad radioassay. Clin Chem 53:781–784, 2007.
98. Kim YI, Pogribny IP, Basnakian AG, et al: Folate deficiency in rats 121. Blackmore S, Pfeiffer CM, Lee A, et al: Isotope dilution-LC-MS/
induces DNA strand breaks and hypomethylation within the p53 MS reference method assessment of serum folate assay accuracy and
tumor suppressor gene. Am J Clin Nutr 65:46–52, 1997. proficiency testing consensus mean. Clin Chem 57:986–994, 2011.
99. Xiao S, Tang YS, Khan RA, et al: Influence of physiologic folate defi- 122. Antony AC: Megaloblastic anemias. In Hoffman R, Benz EJJ, Shattil
ciency on human papillomavirus type 16 (HPV16)-harboring human SJ, et al, editors: Hematology: Basic Principles and Practice, ed 5, Phila-
keratinocytes in vitro and in vivo. J Biol Chem 287:12559–12577, delphia, 2009, Churchill Livingstone Elsevier, pp 491–524.
2012. 123. Farrell CJ, Kirsch SH, Herrmann M: Red cell or serum folate: what to
100. Bull CF, Mayrhofer G, O’Callaghan NJ, et al: Folate deficiency induces do in clinical practice? Clin Chem Lab Med 51:555–569, 2013.
dysfunctional long and short telomeres; both states are associated with 124. Pfeiffer CM, Caudill SP, Gunter EW, et al: Biochemical indicators of
hypomethylation and DNA damage in human WIL2-NS cells. Cancer B vitamin status in the US population after folic acid fortification:
Prev Res (Phila) 7:128–138, 2014. results from the National Health and Nutrition Examination Survey
101. Koike H, Takahashi M, Ohyama K, et al: Clinicopathologic features of 1999-2000. Am J Clin Nutr 82:442–450, 2005.
folate-deficiency neuropathy. Neurology 84:1026–1033, 2015. 125. Green R: Indicators for assessing folate and vitamin B12 status and
102. Kalita J, Misra UK: Vitamin B12 deficiency neurological syndromes: for monitoring the efficacy of intervention strategies. Food Nutr Bull
correlation of clinical, MRI and cognitive evoked potential. J Neurol 29:S52–S63, discussion S4-6, 2008.
255:353–359, 2008. 126. Yetley EA, Pfeiffer CM, Phinney KW, et al: Biomarkers of folate status
103. Misra UK, Kalita J, Das A: Vitamin B12 deficiency neurological in NHANES: a roundtable summary. Am J Clin Nutr 94:303S–312S,
syndromes: a clinical, MRI and electrodiagnostic study. Electromyogr 2011.
Clin Neurophysiol 43:57–64, 2003. 127. Herbert V, Zalusky R: Interrelations of vitamin B12 and folic acid
104. Hemmer B, Glocker FX, Schumacher M, et al: Subacute com- metabolism: folic acid clearance studies. J Clin Invest 41:1263–1276,
bined degeneration: clinical, electrophysiological, and magnetic 1962.
resonance imaging findings. J Neurol Neurosurg Psychiatry 65:822–827, 128. Waters AH, Mollin DL: Observations on the metabolism of folic acid
1998. in pernicious anaemia. Br J Haematol 9:319–327, 1963.
105. Pandey S, Kalita J, Misra UK: A sequential study of visual evoked 129. Cooper BA, Lowenstein L: Relative folate deficiency of erythrocytes
potential in patients with vitamin B12 deficiency neurological syn- in pernicious anemia and its correction with cyanocobalamin. Blood
drome. Clin Neurophysiol 115:914–918, 2004. 24:502–521, 1964.
106. Clemens TL: Vitamin B12 deficiency and bone health. N Engl J Med 130. Saraya AK, Choudhry VP, Ghai OP: Interrelationships of vitamin B
371:963–964, 2014. 12, folic acid, and iron in anemia of infancy and childhood: effect of
107. Tucker KL, Hannan MT, Qiao N, et al: Low plasma vitamin B12 is vitamin B 12 and iron therapy on folate metabolism. Am J Clin Nutr
associated with lower BMD: the Framingham Osteoporosis Study. J 26:640–646, 1973.
Bone Miner Res 20:152–158, 2005. 131. Saraya AK, Singla PN, Ramachandran K, et al: Nutritional macrocytic
108. Cagnacci A, Bagni B, Zini A, et al: Relation of folates, vitamin B12 and anemia of infancy and childhood. Am J Clin Nutr 23:1378–1384,
homocysteine to vertebral bone mineral density change in postmeno- 1970.
pausal women. A five-year longitudinal evaluation. Bone 42:314–320, 132. Nixon PF, Bertino JR: Impaired utilization of serum folate in pernicious
2008. anemia. A study with radiolabeled 5-methyltetrahydrofolate. J Clin
109. Goerss JB, Kim CH, Atkinson EJ, et al: Risk of fractures in patients Invest 51:1431–1439, 1972.
with pernicious anemia. J Bone Miner Res 7:573–579, 1992. 133. Antony AC: Megaloblastic anemias. In Goldman L, Schafer A, editors:
110. Merriman NA, Putt ME, Metz DC, et al: Hip fracture risk in patients Cecil Medicine, ed 25, Philadelphia, 2015, Elsevier-Saunders, Volume
with a diagnosis of pernicious anemia. Gastroenterology 138:1330–1337, 1, Chapter 164, pp 1104–1114.
2010. 134. Oppenheimer SJ, Cashin P: Serum and red cell folate levels associated
111. Kunisawa J, Hashimoto E, Ishikawa I, et al: A pivotal role of vitamin with malarial parasitaemia. Trans R Soc Trop Med Hyg 80:169–171,
B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS 1986.
ONE 7:e32094, 2012. 135. Trager W: The enhanced folic and folinic acid contents of erythrocytes
112. Kishimoto K, Kobayashi R, Sano H, et al: Impact of folate therapy on infected with malaria parasites. Exp Parasitol 8:265–273, 1959.
combined immunodeficiency secondary to hereditary folate malabsorp- 136. Reid VE, Friedkin M: Plasmodium berghei: folic acid levels in mouse
tion. Clin Immunol 153:17–22, 2014. erythrocytes. Exp Parasitol 33:424–428, 1973.
113. Refsum H, Smith AD, Ueland PM, et al: Facts and recommendations 137. Bor MV, Nexo E, Hvas AM: Holo-transcobalamin concentration and
about total homocysteine determinations: an expert opinion. Clin transcobalamin saturation reflect recent vitamin B12 absorption better
Chem 50:3–32, 2004. than does serum vitamin B12. Clin Chem 50:1043–1049, 2004.

