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disorder associated with disturbed myelin metabolism. Am J Hum Genet 69. Antony AC, Hansen DK: Hypothesis: folate-responsive neural tube
85:354–363, 2009. defects and neurocristopathies. Teratology 62:42–50, 2000.
48. Selhub J, Franklin WA: The folate-binding protein of rat kidney. 70. Hansen DK, Streck RD, Antony AC: Antisense modulation of the
Purification, properties, and cellular distribution. J Biol Chem coding or regulatory sequence of the folate receptor (folate binding
259:6601–6606, 1984. protein-1) in mouse embryos leads to neural tube defects. Birth Defects
49. Low PS, Antony AC: Folate receptor-targeted drugs for cancer and Res A Clin Mol Teratol 67:475–487, 2003.
inflammatory diseases. Adv Drug Deliv Rev 56:1055–1058, 2004. 71. Bolton JA, Wood SA, Kennedy D, et al: Retinoic acid-dependent
50. Puig-Kroger A, Sierra-Filardi E, Dominguez-Soto A, et al: Folate recep- upregulation of mouse folate receptor-alpha expression in embryonic
tor beta is expressed by tumor-associated macrophages and constitutes a stem cells, and conservation of alternative splicing patterns. Gene
marker for M2 anti-inflammatory/regulatory macrophages. Cancer Res 230:215–224, 1999.
69:9395–9403, 2009. 72. Snow MH, Bennett D: Gastrulation in the mouse: assessment of cell
51. van der Heijden JW, Oerlemans R, Dijkmans BA, et al: Folate recep- populations in the epiblast of tw18/tw18 embryos. J Embryol Exp
tor beta as a potential delivery route for novel folate antagonists to Morphol 47:39–52, 1978.
macrophages in the synovial tissue of rheumatoid arthritis patients. 73. Saitsu H, Ishibashi M, Nakano H, et al: Spatial and temporal expression
Arthritis Rheum 60:12–21, 2009. of folate-binding protein 1 (Fbp1) is closely associated with anterior
52. Han W, Zaynagetdinov R, Yull FE, et al: Molecular imaging of folate neural tube closure in mice. Dev Dyn 226:112–117, 2003.
receptor beta positive macrophages during acute lung inflammation. 74. da Costa M, Sequeira JM, Rothenberg SP, et al: Antibodies to folate
Am J Respir Cell Mol Biol 53:50–59, 2015. receptors impair embryogenesis and fetal development in the rat. Birth
53. Shen J, Hilgenbrink AR, Xia W, et al: Folate receptor-beta consti- Defects Res A Clin Mol Teratol 67:837–847, 2003.
tutes a marker for human proinflammatory monocytes. J Leukoc Biol 75. Rosenquist TH, Chaudoin T, Finnell RH, et al: High-affinity folate
96:563–570, 2014. receptor in cardiac neural crest migration: a gene knockdown model
54. Kane MA, Elwood PC, Portillo RM, et al: Influence on immunoreactive using siRNA. Dev Dyn 239:1136–1144, 2010.
folate-binding proteins of extracellular folate concentration in cultured 76. Rothenberg SP, da Costa MP, Sequeira JM, et al: Autoantibodies against
human cells. J Clin Invest 81:1398–1406, 1988. folate receptors in women with a pregnancy complicated by a neural-
55. Shatnawi A, Tran T, Ratnam M: R5020 and RU486 act as progesterone tube defect. N Engl J Med 350:134–142, 2004.
receptor agonists to enhance Sp1/Sp4-dependent gene transcription by 77. Iskandar BJ, Rizk E, Meier B, et al: Folate regulation of axonal regenera-
an indirect mechanism. Mol Endocrinol 21:635–650, 2007. tion in the rodent central nervous system through DNA methylation.
56. Antony A, Tang YS, Khan RA, et al: Translational upregulation of J Clin Invest 120:1603–1616, 2010.
folate receptors is mediated by homocysteine via RNA-heterogeneous 78. Zhao R, Min SH, Qiu A, et al: The spectrum of mutations in the PCFT
nuclear ribonucleoprotein E1 interactions. J Clin Invest 113:285–301, gene, coding for an intestinal folate transporter, that are the basis for
2004. hereditary folate malabsorption. Blood 110:1147–1152, 2007.
57. Xiao S, Hansen DK, Horsley ET, et al: Maternal folate deficiency 79. Kozyraki R, Fyfe J, Verroust PJ, et al: Megalin-dependent cubilin-
results in selective upregulation of folate receptors and heterogeneous mediated endocytosis is a major pathway for the apical uptake of trans-
nuclear ribonucleoprotein-E1 associated with multiple subtle aberra- ferrin in polarized epithelia. Proc Natl Acad Sci USA 98:12491–12496,
tions in fetal tissues. Birth Defects Res A Clin Mol Teratol 73:6–28, 2001.
2005. 80. Moestrup SK, Verroust PJ: Megalin- and cubilin-mediated endocytosis
58. Salbaum JM, Finnell RH, Kappen C: Regulation of folate receptor 1 of protein-bound vitamins, lipids, and hormones in polarized epithelia.
gene expression in the visceral endoderm. Birth Defects Res A Clin Mol Annu Rev Nutr 21:407–428, 2001.
Teratol 85:303–313, 2009. 81. Birn H, Zhai X, Holm J, et al: Megalin binds and mediates cellular
59. Tang YS, Khan RA, Zhang Y, et al: Incrimination of heterogeneous internalization of folate binding protein. FEBS J 272:4423–4430,
nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of 2005.
physiological folate deficiency. J Biol Chem 286:39100–39115, 2011. 82. Antony AC, Kincade RS, Verma RS, et al: Identification of high affinity
60. Xiao X, Tang YS, Mackins JY, et al: Isolation and characterization of a folate binding proteins in human erythrocyte membranes. J Clin Invest
folate receptor mRNA-binding trans-factor from human placenta. Evi- 80:711–723, 1987.
dence favoring identity with heterogeneous nuclear ribonucleoprotein 83. Antony AC, Bruno E, Briddell RA, et al: Effect of perturbation of
E1. J Biol Chem 276:41510–41517, 2001. specific folate receptors during in vitro erythropoiesis. J Clin Invest
61. Stover PJ: Folate biochemical pathways and their regulation. In Bailey 80:1618–1623, 1987.
LB, editor: Folate in Health and Disease, ed 2, Boca Raton, FL, 2010, 84. Oppenheim EW, Adelman C, Liu X, et al: Heavy chain ferritin
CRC Press, pp 49–74. enhances serine hydroxymethyltransferase expression and de novo
62. Boshnjaku V, Shim KW, Tsurubuchi T, et al: Nuclear localization of thymidine biosynthesis. J Biol Chem 276:19855–19861, 2001.
folate receptor alpha: a new role as a transcription factor. Sci Rep 2:980, 85. Tibbetts AS, Appling DR: Compartmentalization of mammalian
2012. folate-mediated one-carbon metabolism. Annu Rev Nutr 30:57–81,
63. Antony AC: Folate receptors: reflections on a personal odyssey and a 2010.
perspective on unfolding truth. Adv Drug Deliv Rev 56:1059–1066, 86. Titus SA, Moran RG: Retrovirally mediated complementation of the
2004. glyB phenotype. Cloning of a human gene encoding the carrier for
64. Antony AC: In utero physiology: role of folic acid in nutrient delivery entry of folates into mitochondria. J Biol Chem 275:36811–36817,
and fetal development. Am J Clin Nutr 85:598S–603S, 2007. 2000.
65. Solanky N, Requena Jimenez A, D’Souza SW, et al: Expression of folate 87. Agrimi G, Di Noia MA, Marobbio CM, et al: Identification of the
transporters in human placenta and implications for homocysteine human mitochondrial S-adenosylmethionine transporter: bacterial
metabolism. Placenta 31:134–143, 2010. expression, reconstitution, functional characterization and tissue
66. Antony AC, Utley C, Van Horne KC, et al: Isolation and charac- distribution. Biochem J 379:183–190, 2004.
terization of a folate receptor from human placenta. J Biol Chem 88. Stover PJ: One-carbon metabolism-genome interactions in folate-
256:9684–9692, 1981. associated pathologies. J Nutr 139:2402–2405, 2009.
67. Verma RS, Gullapalli S, Antony AC: Evidence that the hydrophobicity 89. Field MS, Kamynina E, Agunloye OC, et al: Nuclear enrichment
of isolated, in situ, and de novo-synthesized native human placental of folate cofactors and methylenetetrahydrofolate dehydrogenase 1
folate receptors is a function of glycosyl-phosphatidylinositol anchoring (MTHFD1) protect de novo thymidylate biosynthesis during folate
to membranes. J Biol Chem 267:4119–4127, 1992. deficiency. J Biol Chem 289:29642–29650, 2014.
68. Piedrahita JA, Oetama B, Bennett GD, et al: Mice lacking the folic 90. Wickramasinghe SN, Fida S: Bone marrow cells from vitamin B12-
acid-binding protein Folbp1 are defective in early embryonic develop- and folate-deficient patients misincorporate uracil into DNA. Blood
ment. Nat Genet 23:228–232, 1999. 83:1656–1661, 1994.

