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2016 Part XII: Hemostasis and Thrombosis Chapter 117: Thrombocytopenia 2017

TABLE 117–7. Drugs Causing Thrombocytopenia
CASES: 1
Adefovir dipivoxil (1, 0) Diflunisal (0, 1) Isotretinoin (0, 1) Penicillin (0, 1)
Alatrofloxacin (0, 1) Digitoxin (0, 1) Itraconazole (0, 1) Pentoxifylline (1, 0)
Albendazole (0, 1) Diltiazem (0, 1) Lithium (1, 0) Piperazine (0, 1)
Alprenolol (1, 0) Doxepin (0, 1) Lopinavir/ritonavir (1, 0) Primidone (0, 1)
Amlodipine (0, 1) Eflornithine (1, 0) Losartan (0, 1) Pyrazinamide (0, 1)
Anakinra (0, 1) Ezetimibe (0, 1) Mebhydroline (0, 1) Recombinant hepatitis B
Apalcillin (0, 1) Famotidine (0, 1) Meloxicam (0, 1) vaccine (0, 1)
Aspirin (0, 1) Felbamate (0, 1) Meprobamate (0, 1) Rifampicin (1, 0)
Atorvastatin (1, 0) Fenoprofen (0, 1) Mesalamine (1, 0) Rituximab (1, 0)
Bismuth (0, 1) Feprazone (0, 1) Methazolamide (0, 1) Rofecoxib (0, 1)
Butoconazole (0, 1) Finasteride (0, 1) Mexiletine (0, 1) Rosiglitazone (0, 1)
Cefamandole (0, 1) Formestane (0, 1) Minoxidil (1, 0) Sodium stibogluconate
Cephalothin (1, 0) G-CSF (filgrastim) (0, 1) Mirtazapine (0, 1) (0, 1)
Chlorpheniramine (0, 1) Haloperidol (1, 0) Morphine (0, 1) Sulfadiazine (0, 1)
Chlorpromazine (1, 0) Inamrinone (1, 0) Naphazoline (1, 0) Sulfamethoxazole (0, 1)
Ciprofloxacin (0, 1) Indomethacin (0, 1) Nimesulide (0, 1) Sulfathiazole (1, 0)
Clarithromycin (0, 1) Infliximab (0, 1) Nitroglycerin (1, 0) Suramin (0, 1)
Clopidogrel (0, 1) Influenza vaccine (0, 1) Novobiocin (1, 0) Teicoplanin (1, 0)
Deferoxamine (1, 0) Interferon 2b (0, 1) Octreotide (1, 0) Thiothixene (1, 0)
Desipramine (0, 1) Iocetamic acid (0, 1) Oxcarbazepine (0, 1) Tiagabine (0, 1)
Diazepam (1, 0) Iopamidol (0, 1) Oxytetracycline (0, 1) Tolmetin (1, 0)
Diazoxide (1, 0) Iron dextran (0, 1) Penicillamine (0, 1) Tranilast (0, 1)
Diethylstilbestrol (1, 0) Isoniazid (1, 0)
CASES: 2 TO 4
Acetazolamide (1, 2) Etretinate (0, 2) Naproxen (0, 4) Sulindac (0, 2)
Aminoglutethimide (2, 1) Fluconazole (0, 2) Oxaliplatin (0, 2) Sulfamethoxypyridazine
Aminosalicylic acid (2, 1) Glibenclamide (0, 2) Oxprenolol (2, 1) (0, 3)
Amphotericin b (2, 1) Ibuprofen (0, 2) Oxyphenbutazone (0, 2) Sulfasalazine (1, 2)
Ampicillin (0, 2) Indinavir (3, 0) Phenytoin (0, 3) Tamoxifen (2, 1)
Captopril (0, 2) Interferon (0, 4) Piperacillin (1, 1) Terbinafine (0, 2)
Chlordiazepoxide (0, 2) Iopanoic acid (1, 1) Roxifiban (0, 2) Ticlopidine (0, 3)
Chlorothiazide (1, 3) Levamisole (2, 0) Simvastatin (0, 2) Trastuzumab (0, 2)
Digoxin (3, 0) Meclofenamate (2, 0) Sulfapyridine (0, 2) Vancomycin (3, 0)
Ethambutol (1, 1) Methicillin (2, 0)
CASES: 5 TO 10
Abciximab c7e3 Fab (1, 6) Danazol (3, 4) Hydrochlorothiazide (0, 5) Procainamide (0, 7)
Amiodarone (2, 0) Diatrizoate meglumine/ Interferon-α (1, 6) Ranitidine (0, 5)
Acetaminophen (3, 4) diatrizoate sodium (3, 2) Lotrafiban (0, 5) Rifampin (5, 5)
Carbamazepine (0, 10) Diclofenac (2, 3) Methyldopa (3, 3) Sulfisoxazole (1, 4)
Chlorpropamide (0, 5) Efalizumab (Raptiva) (0, 6) Nalidixic acid (1, 5) Tirofiban (1, 6)
Cimetidine (1, 5) Eptifibatide (0, 7)
CASES: >10
Gold (0, 11) Quinidine (26, 32) Quinine (14, 9) Sulfamethoxazole (3, 12)
G-CSF, granulocyte colony-stimulating factor.
Table of drugs that cause thrombocytopenia supported by one or more patient case reports with level I (definite) or level II (probable) clinical
evidence. The table is broken down by the total number of single case reports with the individual number of level I cases and level II reports
denoted in parentheses, respectively. The full list of articles reviewed, the methodology for establishing levels of evidence, and a complete
updated database are available at www.ouhsc.edu/platelets/.
Data from www.ouhsc.edu/platelets/ditp.html.

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