Page 195 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )
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CHAPTER 8  ■  Leukocytes: The Granulocytic and Monocytic Series                                      179




                                                              ,             Mycobacterium tuber-                                x

                   culosis. M                                                                                                  MHC m             (                                ).

                                          m     m    -  x

                                     m  m                                              m                                       Differences in Phagocytosis: Monocytes

                                 mm                   .

                        R                           z  m                                                  -                    M

                                                     q                                     m                  .                                                  m                                                m.

                   M                                                                   k                                       A             m                       m                                           m-

                                                m                 x   . I                      m                               m          m               ,                                .  T       m

                      m                      m    m  m         ,              ,      m                                                           x    m                           ,

                                                                                                     m                         k    m       m               m                      m                               .

                      z  m  .                                                                                                  L                                    -

                        A               -                   “                          ”          m    -                       M.  tuberculosis.  M

                                              .  T                                                  x    z-                                                                  m     m    -  x

                             m                                   x      m                               .                                                                m  m

                   Ox    z           m                                  m                x                                        m                             mm                   .

                                          m                                               . U    z

                                                  m                                                                            Destruction and Debris Removal

                   (NADPH)                                   m                                                                 A                                                    z  m   ,                    m

                   (NADH)                                          q                                                           m  m                                                                          ,
                                                                                                                    -
                         m  m        -             x                                  x      ( O )                                                                                          z            m                  .

                       m   x        . H                     x      (H O )                                                      M                                                                   k


                       m           x                                           z                    x                                                      m                 x   . H           ,

                      m        .
                                                                                                                               m               m                       m    m  m         ,       m


                                                                         -                +         +                                                                                                            m
                                    O       +  NADPH →              O       +  NADP           +  H                                z  m  .

                                         -
                                                    +
                                    O +         H →          HO        +  O
                                                                                                                               Stage 4: Subsequent Phagocytic Activity


                        T    k                       H O                                       m                               I                 m                 m                              z


                              x     -          . T                     q                  z  m   MPO,                                              ,         m                        m                         -
                                           m                                                                .                              ,                      m                                                .

                   A                                                                                                           U                                                                             mm        ,

                   k                               ,          x                                 x                                                                   m                                                 .

                                                                                                                               I                                   m                                     ,              -

                      j                    .                                                                                   m                       . I                                                        -

                                                                                                                                                                                     ,



                                        HO             m              x        →  HOC  HO                                             .
                                                                                        +
                                                                                                                                    I                    q          mm                                  m   (AIDS),
                                                                                                                                                           N            C          I                                    -

                        T     m                              x        -                   m                                                                       m                                     .  I

                   m            m         m                                                      CGD,                                                                                                          m

                                                                                 k                                                 m AIDS             ,                                                       m

                       m                                                         -                       x                                                                              .

                                                   x               m         .                                                      P                                 AIDS                                    m

                        CGD                 m                                                             -                                                                m             . T                          -

                                  m                              z  m          m                                                       m                                                                k

                      x                          . A  q                  x                                                               mm              m,

                                        m                  m              ,                                  -                              k                                    .

                                     m                                         . T          m                                       P      z                  m ,             Leishmania donovani (      -

                                                                                                                                                             kala azar),                               m          -

                                                                                                                                                                                  ,           ,                 m        .

                                                                 k      .                                                      T   Leishman Donovan bodies,                                          ,

                        R                                                  x            ,    m                                 m                                                   .  R               m

                                      m                                                       . I                                              x                 m                        z      m

                                    m          ,                                  m                                                   m                (F   .    .    ).  I

                   major histocompatibility complex  MHC          II                                                                       Histoplasma  capsulatum,
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