Page 191 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 8 ■ Leukocytes: The Granulocytic and Monocytic Series 175

Vasodilation

Edema

Neutrophils
y
t
i
s Monocytes and
n
e
t macrophages
In

1 2 3 4 5

Acute, short- Days

term injury

FIGURE 8.18 m mm . T

, m , -

, m m . (R m
FIGURE 8.17 B m m AIDS M C H. Te Nature o Disease Pathology or the Health
m m . H Pro essions, P , PA: L W m & W k , ,

m m - -µm (W m .)

, m × ). (R m C JD,

. Baum’s extbook o Pulmonary Diseases, , P , PA:

L W m & W k , , m .) (PAMP ) LR . H m -
x m j LR . F m ,

m mm m,

, k k (LAP) - x ( z

m , . T k - [F R ]) m m (CR ). R , -

k (LAP) k - A (IL- A) IL- F, k

C . T LAP m - ,

m k- k k m . m mm .

A mm - A m j

z . I mm - m /m , -

, m mm m k z

m (F . . ). I k - m mm . T mm x ( ),

m m m- mm , -

m (F . . ). m m m .

U mm , mm -

, x m , m k , k , m - PHAGOCY OSIS

,

. N q k D

z - m mm m m .

FIGURE 8.19 S mm

k m .

Neutrophils Monocytes

Phagocytosis
(e.g., microbes) Phagocytosis
Chemokine and (e.g., microbes,
cytokine synthesis apoptotic cells)

Endothelial permeability Chemokine and Mechanisms of
cytokine synthesis PMN-mediated

monocyte
recruitment
granule protein-
Onset of mediated adhesion chemokine synthesis ‘find me’ SIGNALS
inflammation and emigration IL-6 transsignaling of apoptotic neutrophils

1h 12h 24h ....days....