Page 204 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

Principles o Blood Collection and
9 Leukocytes: Lymphocytes and

CHAPTER Plasma Cell
Processings

KEY TERMS

absolute num ber INTERLEUKIN-1 (IL-1) natural killer (NK) lym phocytes

antibodies INTERLEUKIN-2 (IL-2) T-cell growth plasm a cells
antigens factor relative num ber

B cells lym phocyte Rieder’s cells
B lym phocytes lym phocyte recirculation sm udge cells

bursa lym phocytopenia T cells
chem otactic factors lym phocytosis T lym phocytes

cluster of differentiation memory cells thym us
am e cells migration inhibition factor (MIF) variant lym phocytes

hom eostatic proliferation monoclonal antibody vacuolated lym phocytes
im m unocom petent Mott cells

LEARNING OUTCOMES OBJECTIVES

Lymphopoiesis: Anatomical origin and Morphological characteristics of normal

development of lymphocytes lymphocytes

■ Brie y describe the role of lymphocytes and plasma cells in the body ■ Compare the characteristics, such as chromatin patterns, of the

defense mechanism against disease. three major developmental stages of lymphocyte maturation.

■ Name and locate the two primary and three secondary lymphoid ■ Discuss the morphological abnormalities of speci c variant (acti-

tissues. vated or reactive) lymphocytes.

■ Identify the anatomical sites populated by T cells and B cells. State at least three conditions associated with speci c lymphocytic

abnormalities that may be seen in peripheral blood.
Lymphocyte kinetics: Life span and

proliferation Characteristics of lymphocytes

■ Compare the length of the life span of the T and B lymphocytes. ■ Differentiate the functions of the three major categories of
Summarize what in uences proliferation of T and B lymphocytes in lymphocytes.

primary and secondary lymphoid tissues. Compare the functional differences between various subtypes of

Explain homeostatic proliferation of lymphocytes. B cells.

Explain the antibody-independent roles for B cells in immune
Lymphocyte kinetics: Recirculation of responses.

lymphocytes Brie y describe the production and laboratory application of mono-

■ Explain the process and importance of lymphocyte recirculation. clonal antibodies.

Describe the migration of naive T cells from blood to tissue.
Major lymphocyte membrane characteristics

Normal reference values and development

■ Compare absolute and relative numbers of lymphocytes. ■ Describe the production of monoclonal antibodies.

■ Calculate the absolute value of a lymphocyte example. ■ Brie y describe membrane marker development in T cells.

■ Cite the percentage of T and B cells found in the peripheral circula- Summarize major lymphocytic phenotypes and the molecular char-
tion of adults. acteristics used to differentiate lymphocyte subsets.

■ Compare the major types, normal reference value percentages, and ■ Name four cytokines or chemokines produced by T cells and describe
quantities of lymphocytes at different ages ranging from birth to their function.

adulthood. ■ Name several applications of lymphocyte subset testing.

■ De ne the terms lymphocytopenia and lymphocytosis. Compare and contrast the immunologic features and major function
Classify conditions associated with an increase or decrease in of T B, and natural killer (NK) cells.
,
the absolute number and relative values in the peripheral blood

circulation.

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