Page 205 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 9 ■ Leukocytes: Lymphocytes and Plasma Cells 189

T lymphocytes, B lymphocytes, and plasma cell Differentiate the characteristics between short-lived and long-lived

kinetics plasma cells.

Describe the activation and function of T cells, B cells, and ■ Describe the appearance and cytoplasmic contents of Russell’s bod-

plasma. ies, Mott cells, and ame cells.

Plasma cell development and maturation NOTE:

■ Describe the pathway of plasma cell development. ■ Indicates MLT and MLS core content

■ Identify the maturational characteristics of plasma cells. Indicates MLT (optional) and MLS advanced content

k . T q m -
ANA OMICAL ORIGIN AND

DEVELOPMEN OF LYMPHOCY ES m immunocompetent ( -
mm ) m . I

I , m , m q

m ( C ), lymphocytes m . I m m bursa B m

plasma cells m . M m

antigens ; m m

antibodies. .

Secondary Lym phoid Tissue
Sites of Lymphocytic Development
T m m

D m m , m m (F . . ), , P ’ (
k .

L m ,
m m m -

m . C m
interleukin-1 (IL-1) IL-

m m . C m Palatine tonsil
m Adenoids

m m . H m Lingual tonsil
m Thymus

-B m . T m j
T lymphocytes B lymphocytes Nodes gland

( . ). A m B .

Prim ary Lym phoid Tissue

I m , m thymus - Spleen

m m (F . . )
m . S m m

m

Approximate Percentage of T and B
TABLE 9.1
Lymphocytes in Lymphoid Organs

Lymphoid T Lymphocytes B Lymphocytes

Organ (%) (%)

Appendix Peyer patches
Thymus 100 0 (in intestine)

Blood 80–85 10-15

Lymph nodes 60 40

Spleen 45 55
FIGURE 9.1 L m . (R -
Bone marrow 10 90 m m C BJ, JJ. Memmler’s T e Human Body

Modi ed from Claman HN. J Am Med Assoc. 1992;268(20):2792. in Health and Disease, , B m , MD: W K
H , .)