Page 431 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

22 Lymphoid and Plasma Cell

CHAPTER Neoplasms

KEY WORDS

angiogenesis cytogenetics multiple myeloma

aneuploidy hairy cell leukem ia näive B cells
apoptosis Hodgkin disease non-Hodgkin lym phom a

B-cell prolym phocytic leukem ias hyperviscosity plasm a cell leukem ia
chem otherapy leukem ias Reed-Sternberg cells

chronic lym phocytic leukem ia lym phom as Waldenström m acroglobulinem ia
clonal minimal residual disease

cryoglobulins mucosa-associated lymphoid tissue

LEARNING OUTCOMES

Leukemias and lymphomas ■ Discuss the epidemiology, clinical signs and symptoms, laboratory

■ Compare the characteristics of leukemias and lymphomas. characteristics, and prognosis of Sézary syndrome.

■ Describe the types of specimens and methods of analysis used to Discuss the laboratory characteristics, including phenotyping, of
study leukemias and lymphomas. T-cell large granular lymphocytic leukemia (LGL).

Discuss the etiology and laboratory characteristics of adult T-cell
Chronic lymphocytosis leukemia/lymphoma (HTLV-1).

■ Name various categories with benign or malignant conditions that Lymphomas
produce chronic lymphocytosis.
■ Explain general characteristics of a malignant lymphoma.

Chronic lymphocyte leukemia/ small ■ Name factors known to be risk factors in the development of lym-

lymphocytic lymphoma phoid neoplasms.
■ Describe the two contemporary lymphoma classi cation systems,
■ Describe the diagnostic features, including clinical symptoms and including how subtypes are classi ed.
laboratory data, of chronic lymphocytic leukemia (CLL). ■ Identify the epidemiologic characteristics of lymphomas.

■ Explain the usefulness of chromosome analysis and molecular anal- Summarize the pathophysiology of most lymphomas.
ysis in the diagnosis and prognosis of CLL. ■ Describe the laboratory analysis of lymphoid neoplasms.

■ Describe the features associated with aggressive forms of CLL. Summarize and compare disorders that represent the leukemic

■ Explain the systems to stage disease and progress.
phase of non-Hodgkin lymphomas: follicular lymphoma, mantle cell

Monoclonal B-cell lymphocytosis (MBL) lymphoma (MCL), marginal zone B-cell lymphoma, lymphoplasma-
cytic lymphoma (LPL), diffuse large B-cell lymphoma, not otherwise
Compare the differences between low count and high count speci ed (DLBCL,NOS), and Burkitt’s lymphoma.

in MBL
■ Explain the etiology, epidemiology, laboratory characteristics, and

B-cell prolymphocytic leukemia (B-PLL) prognosis of Hodgkin disease.

Discuss the epidemiology, clinical signs and symptoms, laboratory Plasma cell dyscrasias

characteristics and treatment of B-PLL. ■ Name disorders based on proliferation of plasma cells and abnormal

production of immunoglobulins.

Hairy cell leukemia ■ Describe the general characteristics and laboratory data in multiple

■ Discuss the epidemiology, clinical signs and symptoms, laboratory myeloma.
characteristics and treatment of hairy cell leukemia (HCL). Identify recent changes to the diagnostic criteria for multiple

■ Describe laboratory ndings seen in the variant form of HCL. myeloma with speci c biomarkers.
Compare laboratory characteristics of multiple myeloma,
T-cell and NK-cell neoplasms Waldenström’s macroglobulinemia, plasma cell leukemia (PCL),

Discuss the epidemiology, clinical signs and symptoms, laboratory heavy chain disease, and monoclonal gammopathy of undetermined

characteristics and treatment of T-cell prolymphocytic leukemia. signi cance (MGUS).

415