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122 SECTION THREE ERYTHROCYTES
b-THALASSEMIA MAJOR
0 0
1 1
b b b b b b db Lepore /db Lepore
0 1
A B
FIGURE 13–3A b-Thalassemia major (PB 3500). FIGURE 13–3B b-Thalassemia major (PB 31000).
Peripheral Blood: Marked variation in size and shape, numerous nucleated erythrocytes,
microcytes, hypochromia, target cells, basophilic stippling, tear drop cells, schistocytes,
polychromasia
a-THALASSEMIA*
Hemoglobin H
22/2a
Peripheral Blood: Microcytes, hypochromia, marked poikilocytosis, target cells, polychromasia
(see Figure 12-5, C).
*a-Thalassemia minor (22/aa,2a/2a) has red cell morphology similar to b-thalassemia minor
and as such is not represented here.
