Page 184 - Clinical Hematology Atlas

168 SECTION FOUR LEUKOCYTES

yeloproliferative neoplasms are clonal hematopoietic stem cell diseases with expansion,
Mexcessive production, and overaccumulation of erythrocytes, granulocytes, and platelets
individually or in some combination.
The World Health Organization classification of tumors of the hematopoietic and
lymphoid tissues has divided these disorders into four major categories:
1
1. Chronic myelogenous leukemia, BCR-ABL1 (CML)
2. Polycythemia vera (PV)
3. Essential thrombocythemia (ET)
4. Primary myelofibrosis (PMF)
These neoplasms have common clinical features, laboratory findings, and pathogenetic
similarities (Table 17-1).