Page 182 - Clinical Hematology Atlas

166 SECTION FOUR LEUKOCYTES

ACUTE LYMPHOBLASTIC LEUKEMIA, LARGE BLASTS

A B
FIGURE 16–2A Peripheral blood (31000). FIGURE 16–2B Bone marrow (3500).

MORPHOLOGY
Peripheral Blood: Blasts—two to three times the
size of a resting lymphocyte, moderate cytoplasm,
irregular nuclear membrane, prominent nucleoli,
thrombocytopenia, morphologically difficult to
distinguish from acute myeloid leukemia
Bone Marrow: $20% of all nucleated cells
comprise a heterogeneous population of blasts

C
FIGURE 16–2C Bone marrow (31000).