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160                                HIGHSMITH ET AL.



      foot, which utilized a carbon fiber keel and ankle;   study compared VO2 peak attained during running
      and a running-specific ESAR foot, which utilized a   for two TFA runners utilizing both a conventional
      carbon fiber C-shaped keel but was heelless. During   running prosthesis with an articulating knee mech-
      walking for TFA, at both fixed speeds and self-selected   anism and a prosthesis that had a non-articulating
      walking speeds (SSWS), no significant differences   knee joint (3). Results were mixed in that VO2 peak
      were observed for energy costs (VO2, gait economy,   was higher for one subject using the prosthesis with
      gait efficiency (GE)) among the three prosthetic   an articulating knee mechanism and one subject using
      feet conditions. However, at SSWS, TFA patients   the prosthesis that had the non-articulating knee
      demonstrated significantly improved speed with the   joint. However, both subjects were able to run longer
      general-purpose ESAR foot and running-specific   and attained faster speeds using the prosthesis that
      ESAR foot compared to the SACH foot (7% and 9%   had the non-articulating knee joint. Based on their
      respectively).                                results, these researchers suggested that a prosthe-
        Studies reporting the effects of prosthetic foot   sis with a non-articulating knee joint may be more
      components on energy costs and ambulatory per-  energy efficient for TFA runners. However, this study
      formance for TFA patients during running are very   had several limitations. It utilized only two subjects,
      limited. In their study, Mengelkoch et al. (2) reported   did not specify an accommodation period for TFA
      that TFA patients were not safely able to utilize the   patients to utilize each type of prosthesis, performed
      SACH foot during running. They observed that TFA   the maximal exercise tests for both prostheses with
      participants were able to run at speeds up to their   only a 30 min rest between tests, and did not include
      self-selected running speeds (SSRS) using the gen-  information concerning ratings of perceived exertion
      eral purpose ESAR foot and the running-specific   during testing or subjective preference for running
      ESAR foot. At SSRS, the speed deemed comfort-  with each type of running prosthesis.
      able for sustained distance running, GE was similar     Given the limitations in the study by Wening et al.
      for TFA subjects using the general-purpose ESAR   (3), the purpose of this study was to further examine
      foot and the running-specific ESAR foot. However,   potential bioenergetic differences for TFA patients
      a functional difference was that SSRS was signifi-  utilizing a conventional running prosthesis with an
      cantly slower using the general-purpose ESAR foot   articulating knee mechanism versus a running pros-
      (13%) compared to the running-specific ESAR foot.   thesis that has a non-articulating knee joint.
      Another important observation from this study was
      that TFA participants were only able to run at speeds   METHODS
      greater than SSRS using the running-specific ESAR
      foot. These researchers recommended that clinicians   Subjects
      should recommend and prescribe a running-specific     Two male and two female (n = 4) unilateral TFA
      ESAR foot for TFA runners interested in performing   runners with amputation due to non-vascular causes
      more vigorous distance-type running (i.e., for exercise   were recruited (Table 1). Participants were healthy
      and running competition).                     recreational runners (K4, Medicare Functional Clas-
        It has been observed that some TFA distance   sification Level), age ≤45 years, who performed run
                                                                     -1
                                                                                  -1
      runners prefer to run with a prosthesis that has a   training 3 to 5 d·week  for ≤30 min·d  for ≥1 year.
      non-articulating knee joint (i.e., a no-knee condition,   The study was conducted in accordance with ethical
      in which a straight pylon attaches to the prosthetic   standards recommended by the Belmont Report (4).
      socket and foot components). Anecdotally, it has   The study protocol was approved by the University of
      been suggested that, during running, increased   South Florida’s Institutional Review Board, and each
      energy may be required for TFA patients to control   study participant provided written informed consent.
      the prosthetic articulating knee to prevent it from
      buckling, compared to a prosthesis with a non-ar-
      ticulating knee joint (3). Previously, a preliminary
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