Page 36 - OCCUPATIONAL EXPOSURE GUIDELINE

01.FA 4/23/09 11:13 AM Page 29

APPENDIX 7

RECOMMENDED POST EXPOSURE PROPHYLAXIS (PEP) FOR EXPOSURE TO
HEPATITIS B VIRUS

Treatment
Vaccination
and antibody
response Source unknown or
status of Source Source not available for
+
+
exposed HBsAg positive HBsAg negative testing
workers 1

HBIG*x1 and initiate Initiate HB Initiate HB
Unvaccinated
HB vaccine series # vaccine series vaccine series
Previously vaccinated

Known
No treatment No treatment No treatment
responder 2

HBIG x1 and initiate If known high risk
Known non- revaccination or HBIG No treatment source, treat as if source
responder 3
x2** were HBsAg positive
29
Test exposed person for
anti-HBs

Test exposed person for 1. If adequate
anti-HBs++ antibody to
HBsAg, no
2
1. If adequate , no
treatment is
Antibody treatment is
necessary
response necessary No treatment
unknown 2. If inadequate
3
2. If inadequate , antibody to
administer HBIG HBsAg,
x1 and vaccine administer
booster
vaccine booster
and recheck titre
in 1-2 months

Guidelines On Occupational Exposures To Human Immunodeficiency
Virus (HIV), Hepatitis B Virus (HBV) And Hepatitis C Virus,
And Recommendations For Post Exposure Prophylaxis (PEP)