Page 10 - 12. Osteoarthritis
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                                                                                                        PATHOPHYSIOLOGY










             • Decrease in proteoglycan content in the matrix



             • Articular cartilage become softening, fraying, flake off



             • The wear and tear process, the cartilage becomes thin and

                 eroded completely from bones



             • The underlying bone (subchondrial bone - providing support


                 for the cartilage of the articular surface) surface become


                 exposed



             • The unprotected bone become sclerotic (dense and hard)
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