Page 12 - PULMONARY ARTERIAL HYPERTENSION

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Pathophysiology

Increased pulmonary vascular resistance is the main pathogenic

mechanism in pulmonary arterial hypertension (PAH).

This is typically due to vasoconstriction, remodeling, and thrombosis

of the small pulmonary arteries and arterioles.

On pathology, patients with PAH are found to have hyperplasia and

hypertrophy of the intima, media, and adventitia of the pulmonary

arterial vasculature.