Page 20 - Respiratory Failure
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Pathophysiology
There are four stages in the development of ARDS.
1. Inflammatory stage.
• It occurs within first 12 hours of an insult/injury.
• Any direct or indirect injury to the lung stimulates the immune system to produce neutrophils,
macrophages and platelets.
• These cells accumulate at the site of an injury in the lungs.
• Further, these cellular mediators initiate the humoral mediators Cytokines, causing damage to
the alveolar capillary membrane
