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Lidocaine (Lignocaine) - Na channel

blocker class IB

• Not Used orally Due to extensive first pass effect

Mechanism :
1)

2) Blocks Na+ channels → ↓ conduction in atria & ventricle
3)

4) Opens K+ channels→Accelerates repolarization ( action potential duration
& RP).

Uess:

ventricular dysrhythmias that is associated with surgery o with Digoxin

toxicity

Side efectsw:

Central nervous system (CNS) effects: include nystagmus (early indicator of
toxicity), drowsiness, slurred speech, paraesthesia, agitation, confusion,

and convulsions, which often limit the duration of continuous infusions.

• Precautions and interaction

1) Not used in patient with impaired hepatic function
2) Lidocaine used as local anesthetics (with epinephrine