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3.3 PrEP clients in People Who Injecting Drugs (PWID)

                              Perceived risk of HIV infection among PWIDs
                       Majority of PWIDs started using drugs from inhaling before switching to injection due to
               rapid  onset  and  longer  duration  of  action  which  resulted  to  cost  saving.  Once  they  became

               injection drug users, they would no longer use non-injection administration i.e. inhalation.

                       Those who were in settings located nearby Drug User Networks were able to access to
               free  clean  needles  and  syringes  while  PWIDs  in  rural  settings  were  more  likely  to  use  their

               syringes repeatedly due to low socioeconomic status.  Majority of PWIDs usually avoided sharing
               needles and syringes due to the risk in acquiring HIV and other infections.  However, this was

               inevitable in case of unavailability of new syringes and they needed the drugs urgently.

                              PrEP awareness among PWIDs
                       Among  PWIDs  who  had  never  heard  about  PrEP,  upon  learning  about  PrEP,  most

               participants were interested in taking PrEP to reduce their risks of HIV infection and confident
               that  they  would  be  able  to  adhere  to  medications  while  some  participants  were  concerned
               regarding their adherence to therapy.


                       Among  PWIDs  who  were  aware  of  PrEP,  there  were  those  who  had  previously
               discontinued PrEP and current PrEP users. The main reason of PrEP discontinuation was due to

               concerns  regarding  adverse  events  whereas  alarm-clock  based  reminder  was  reported  to
               facilitate good adherence among PWIDs who were current PrEP users.

                       According  to  respondents,  increased  access  by  expanding  PrEP  services  in  various

               locations nearby methadone clinics would be essential to improve PrEP uptake among PWIDs
               as well as more promotion of PrEP services to improve public understanding and awareness of

               PrEP in wider populations.

                       3.4 PrEP service providers

                              From  quantitative  analysis,  PrEP  service  providers  in  Thailand  have  positive
               attitudes towards PrEP.  Majority of participants reported a high level of perceived knowledge in
               PrEP and supported PrEP provision in all high-risk groups with residual concern regarding impact

               of  PrEP  on  anti-retroviral  drug  resistance.  In  terms  of  service  delivery  experiences,  most
               respondents perceived that PrEP would not lead to increase risk behaviors (risk compensation).

               Nearly  all  respondents  perceived  that  PrEP  costs  less  than  care  for  HIV  and  discerned  the
               importance of providing PrEP service together with condoms and STIs testing/counselling.  PrEP
               was perceived to be effective in all risk groups including MSMs, TGW, serodiscordant couples,

               PWIDs, and sex workers (Figure 2).





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