Page 52 - R2017 Final_BE Biomedical Curriculum and Syllabus - REC

Department of BME, REC

BM17403 PATHOLOGY AND MICROBIOLOGY L T P C
3 0 0 3

OBJECTIVES:
• Gain knowledge on the structural and functional aspects of living organisms.
• Know the etiology and remedy in treating the pathological diseases.
• Empower the importance of public health.

UNIT I CELL DEGENERATION, REPAIR AND NEOPLASIA 9
Cell injury - Reversible cell injury and Irreversible cell injury and Necrosis, Apoptosis, Pathological
calcification- Dystrophic and Metastatic. cellular adaptations of growth and differentiation,
Inflammation and Repair including fracture healing, Neoplasia, Classification, Benign and
Malignant tumours, carcinogenesis, spread of tumours. Autopsy and biopsy.

UNIT II FLUID AND HEMODYNAMIC DERANGEMENTS 9
Edema, Hyperemia/Ischemia, normal hemostasis, thrombosis, disseminated intravascular
coagulation, embolism, infarction, shock. Hematological disorders-Bleeding disorders,
Leukaemias, Lymphomas.

UNIT III MICROBIOLOGY 9
Normal flora of the human body. Routes of infection and spread; endogenous and exogenous
infections, Morphological features and structural organization of bacteria, growth curve,
identification of bacteria , culture media and its types , culture techniques and observation of
culture. Disease caused by bacteria, fungi, virus.

.UNIT IV IMMUNOPATHOLOGY 10
Antigen, antibody – Immunoglobulins, Immunity - Innate and Acquired. Antigen –antibody
reactions: precipitation, agglutination, complement fixation test, neutralization test, opsonization,
immunofluorescence, immunoelectrophoresis, RIA and ELISA. Hypersensitivity reaction and its
types. Monoclonal antibody production and its applications.

UNIT V MICROSCOPES 8
Light microscope – bright field, dark field, phase contrast, fluorescence, Electron microscope (TEM
& SEM). Preparation of samples for electron microscope.
TOTAL: 45 PERIODS
OUTCOMES:
On completion of the course students will be able to
• Analyze the pathological aspects of various abnormalities.
• Outline the origin/cause of various fluid imbalance and hematological disease.
• Comprehend about the normal flora and how microbes harm us by causing disease.
• Illustrate the interaction of cellular and molecular components of immune system.
• Explain the various functional aspects of microscope.

TEXT BOOKS:
1. Ramzi S Cotran, Vinay Kumar & Stanley L Robbins, “Pathologic Basis of Diseases”, 7th
edition,WB Saunders Co. 2005.
2. Ananthanarayanan & Panicker, “Textbook of Microbiology” , University press (India)
th
Private Limited, 10 edition, 2017.

REFERENCES:
1. Churchill Livingstone “Underwood JCE: General and Systematic Pathology”, 3rd edition,
2000.

Curriculum and Syllabus | B.E Biomedical Engineering | R 2017 Page 52