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Endotoxin Retentive Filter Performance
• Logarithmic reduction value (LRV) for bacteria /endotoxin
= log (A/B)
10
A = viable test bacteria /endotoxin in 1000 mL test solution
B = viable test bacteria /endotoxin in 1000 mL filtrate
• JSDT standard (2011)
Standard dialysis fluid : bacteria < 100 CFU/mL endotoxin < 0.05 EU/mL
Ultrapure dialysis fluid : bacteria < 0.1 CFU/m endotoxin < 0.001 EU/mL
-6
Sterile (substitution) fluid : bacteria < 10 CFU/mL endotoxin < 0.001 EU/mL
• ETRF for obtaining ultrapure dialysis fluid
- LRV for bacteria at least 4 (usually >7)
- LRV for endotoxin at least 2 (usually >3)
Therapeutic Apheresis and Dialysis 2013: 17(2):229-240
