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Etiologies of IDH

2. Impaired peripheral vasoconstriction

 Patient-related factor

 Autonomic neuropathy (DM, uremic neuropathy)

 Antihypertensive medication

 Anemia

 Food ingestion (splenic vasodilatation)

 Decrease sensitivity of the RAAS and AVP system

 Tissue ischemia (adenosine mediated)

 Bacterial sepsis

 Increase in core body temperature

Clin J Am Soc Nephrol . 2018 Aug 7;13(8):1297-1303.